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Mouse Anti-SCN11A Recombinant Antibody (6E1) (CBMAB-A7927-LY)


See all SCN11A antibodies
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Summary

Host Animal
Mouse
Specificity
Human
Clone
6E1
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SCN11A (NP_054858, 1726 a.a. ~ 1791 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
sodium channel, voltage-gated, type XI, alpha subunit
Introduction
Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM
Entrez Gene ID
11280
UniProt ID
Q9UI33
Alternative Names
NAV1.9; NaN; SCN12A; SNS-2
Function
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
Biological Process
Biological Process establishment of localization in cellIEA:Ensembl
Biological Process membrane depolarization during action potentialManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neuronal action potentialManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of ion transmembrane transportIEA:UniProtKB-KW
Biological Process regulation of sensory perception of painISS:UniProtKB
Biological Process response to xenobiotic stimulusManual Assertion Based On ExperimentTAS:ProtInc
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sodium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Involvement in disease
Neuropathy, hereditary sensory and autonomic, 7 (HSAN7):
A form of hereditary sensory and autonomic neuropathy, a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN7 is characterized by congenital inability to experience pain resulting in self-mutilations, slow-healing wounds, and multiple painless fractures. mild muscle weakness, delayed motor development, slightly reduced motor and sensory nerve conduction velocities, hyperhidrosis and gastrointestinal dysfunction.
Episodic pain syndrome, familial, 3 (FEPS3):
An autosomal dominant neurologic disorder characterized by paroxysmal pain mainly affecting the distal lower extremities and occasionally the upper body, especially the joints of fingers and arms. The pain is exacerbated with fatigue.
PTM
Phosphorylation at Ser-1341 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
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For research use only. Not intended for any clinical use.

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