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Mouse Anti-SV2C Recombinant Antibody (CBT3196) (V2LY-0625-LY1818)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3196
Antibody Isotype
IgG1
Application
IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human SV2C (AA: extra mix) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
synaptic vesicle glycoprotein 2C
Entrez Gene ID
22987
Function
Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.
(Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin probably binds via extracellular loop 4 (PubMed:27313224).
Recognition by BoNT/A relies on both protein-protein and protein-N-glycosylation; glycosylation of Asn-559 increases its affinity for BoNT/A (PubMed:27313224).
Also serves as a receptor for the closely related C.botulinum neurotoxin type A2; glycosylation is not essential but enhances the interaction (PubMed:29649119).
(Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); note that type D does not usually infect humans.
Biological Process
Biological Process chemical synaptic transmissionIEA:InterPro
Biological Process neurotransmitter transportIEA:UniProtKB-KW
Cellular Location
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas.
Topology
Cytoplasmic: 1-154
Helical: 155-175
Extracellular: 176-191
Helical: 192-212
Cytoplasmic: 213-226
Helical: 227-247
Extracellular: 248
Helical: 249-269
Cytoplasmic: 270-280
Helical: 281-301
Extracellular: 302-320
Helical: 321-341
Cytoplasmic: 342-437
Helical: 438-458
Extracellular: 459-578
Helical: 579-599
Cytoplasmic: 600-609
Helical: 610-630
Extracellular: 631-636
Helical: 637-657
Cytoplasmic: 658-669
Helical: 670-690
Extracellular: 691-698
Helical: 699-719
Cytoplasmic: 720-727
PTM
N-glycosylated. Upon expression in a kidney cell line the most abundant glycan on Asn-534 is GlcNAc3Hex5, while on Asn-559 and Asn-565 the most abundant glycan is GlcNAc2Fuc1Man3GlcNAc3Gal3. Both Asn-559 and Asn-565 have a high degree of glycan heterogeneity (PubMed:27313224).
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For research use only. Not intended for any clinical use.

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