Rabbit Anti-UPK1A Recombinant Antibody (CBCNC-802) (CBMAB-C4701-CN)

Name: Rabbit Anti-UPK1A Recombinant Antibody (CBCNC-802)
SKU: CBMAB-C4701-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBCNC-802

Application

Immunogen

Synthetic peptide within Human Uroplakin Ia aa 100-200. The exact sequence is proprietary.

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1.618 mg/mL

More Infomation

Target

Full Name

Uroplakin 1A

Introduction

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Entrez Gene ID

Human	11045
Mouse	109637
Rat	365227

UniProt ID

Human	O00322
Mouse	Q9D132
Rat	A0A1L2C162

Alternative Names

Uroplakin 1A; Tetraspanin-21; Uroplakin Ia; Tspan-21; TSPAN21; UP1A; UPIA; UPKA; Uroplakin-1a;

Function

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).

Biological Process

Biological Process epithelial cell differentiation Source:UniProtKB1 Publication

Cellular Location

Membrane

Topology

Cytoplasmic: 1-14
Helical: 15-35
Extracellular: 36-59
Helical: 60-86
Cytoplasmic: 87-91
Helical: 92-112
Extracellular: 113-230
Helical: 231-252
Cytoplasmic: 253-258

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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