Mouse Anti-WDR45B Recombinant Antibody (CBWJW-134) (CBMAB-W0282-WJ)

Name: Mouse Anti-WDR45B Recombinant Antibody (CBWJW-134)
SKU: CBMAB-W0282-WJ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBWJW-134

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat, Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

WD Repeat Domain 45B

Introduction

WDR45B is a protein-coding gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. Diseases associated with WDR45B include Spastic Cerebral Palsy. An important paralog of this gene is WDR45.

Entrez Gene ID

Human	56270
Mouse	66840
Rat	360682

UniProt ID

Human	Q5MNZ6
Mouse	Q9CR39
Rat	Q2MCP5

Alternative Names

WIPI3; WDR45L; WIPI-3

Function

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:28561066).
Binds phosphatidylinositol 3-phosphate (PtdIns3P), and other phosphoinositides including PtdIns(3,5)P2, forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2 (PubMed:28561066, PubMed:30797857).
In the cellular response to starvation, may also function together with the TSC1-TSC2 complex and RB1CC1 in the inhibition of the mTORC1 signaling pathway (PubMed:28503735).

Biological Process

Biological Process autophagosome assembly Source:UniProtKB1 Publication
Biological Process autophagy of mitochondrion Source:GO_Central1 Publication
Biological Process autophagy of nucleus Source:GO_Central1 Publication
Biological Process cellular response to starvation Source:UniProtKB1 Publication
Biological Process protein lipidation Source:GO_Central1 Publication
Biological Process protein localization to phagophore assembly site Source:GO_Central1 Publication

Cellular Location

Preautophagosomal structure
Lysosome

Involvement in disease

Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures (NEDSBAS):
An autosomal recessive disorder characterized by profound developmental delay, progressive spastic quadriplegia and contractures, early-onset refractory epilepsy in most patients, and brain malformations. Neuroimaging shows ventriculomegaly, reduced cerebral white matter volume, and thinning of cerebral gray matter.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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