FIGNL1

This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts.

fidgetin-like 1

Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376).

May play a role in the control of male meiosis dynamic (By similarity).

ATP metabolic process Source: UniProtKB
Cellular response to ionizing radiation Source: UniProtKB
Cytoplasmic microtubule organization Source: GO_Central
Male meiotic nuclear division Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
Osteoblast differentiation Source: UniProtKB
Osteoblast proliferation Source: UniProtKB
Regulation of cell cycle Source: UniProtKB
Regulation of double-strand break repair via homologous recombination Source: UniProtKB

Cytoplasm; Nucleus; Perinuclear region. Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment (PubMed:23754376).