FIGNL1

This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts.

Full Name

fidgetin-like 1

Function

Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376).

May play a role in the control of male meiosis dynamic (By similarity).

Biological Process

ATP metabolic process Source: UniProtKB
Cellular response to ionizing radiation Source: UniProtKB
Cytoplasmic microtubule organization Source: GO_Central
Male meiotic nuclear division Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
Osteoblast differentiation Source: UniProtKB
Osteoblast proliferation Source: UniProtKB
Regulation of cell cycle Source: UniProtKB
Regulation of double-strand break repair via homologous recombination Source: UniProtKB

Cellular Location

Cytoplasm; Nucleus; Perinuclear region. Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment (PubMed:23754376).