Mouse Anti-FIGNL1 Recombinant Antibody (CBXF-1748) (CBMAB-F3283-CQ)

This product is a mouse antibody that recognizes FIGNL1. The antibody CBXF-1748 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all FIGNL1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

CBXF-1748

Antibody Isotype

IgG

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

fidgetin-like 1

Introduction

This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts.

Entrez Gene ID

Human	63979
Mouse	60530
Rat	289777

UniProt ID

Human	Q6PIW4
Mouse	Q8BPY9
Rat	Q6GX84

Alternative Names

Fidgetin Like 1; Fidgetin-Like 1; EC 3.6.4.-; EC 3.6.4;

Function

Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376).

May play a role in the control of male meiosis dynamic (By similarity).

Biological Process

ATP metabolic process Source: UniProtKB
Cellular response to ionizing radiation Source: UniProtKB
Cytoplasmic microtubule organization Source: GO_Central
Male meiotic nuclear division Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of intrinsic apoptotic signaling pathway Source: Ensembl
Osteoblast differentiation Source: UniProtKB
Osteoblast proliferation Source: UniProtKB
Regulation of cell cycle Source: UniProtKB
Regulation of double-strand break repair via homologous recombination Source: UniProtKB

Cellular Location

Cytoplasm; Nucleus; Perinuclear region. Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment (PubMed:23754376).

References

Meng, C., Yang, Y., Ren, P., Ju, Q., Jin, X., Long, Q., ... & Li, F. (2022). FIGNL1 is a potential biomarker of cisplatin resistance in non-small cell lung cancer. The International Journal of Biological Markers, 37(3), 260-269.

Stok, C., van den Tempel, N., Everts, M., Wierenga, E., Bakker, F., Kok, Y., ... & van Vugt, M. (2022). The FIGNL1-interacting protein C1orf112 is synthetic lethal with PICH and mediates RAD51 retention on chromatin. bioRxiv.

Carpio, E. P., Dessapt, J., Villot, R., Sacre, L., Malina, A., Boulais, J., ... & Orthwein, A. (2022). C1orf112 is a novel regulator of interstrand crosslink that decreases FIGNL1-RAD51 interaction. bioRxiv.

Zhen, Z., Li, M., Zhong, M., Ye, L., & Ma, X. (2022). FIGNL1 Expression and its Prognostic Significance in Pan-cancer Analysis. Combinatorial Chemistry & High Throughput Screening.

Li, M., Rui, Y., Peng, W., Hu, J., Jiang, A., Yang, Z., & Huang, L. (2021). FIGNL1 promotes non‑small cell lung cancer cell proliferation. International journal of oncology, 58(1), 83-99.

Matsuzaki, K., Kondo, S., Ishikawa, T., & Shinohara, A. (2019). Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase. Nature communications, 10(1), 1-15.

Atkins, M., Gasmi, L., Bercier, V., Revenu, C., Del Bene, F., Hazan, J., & Fassier, C. (2019). FIGNL1 associates with KIF1Bβ and BICD1 to restrict dynein transport velocity during axon navigation. Journal of Cell Biology, 218(10), 3290-3306.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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