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Mouse Anti-7-Methylguanosine Recombinant Antibody (V2-7673) (CBMAB-1845CQ)

This product is a mouse monoclonal antibody that recognizes 7-Methylguanosine. The antibody 150-15 can be used for immunoassay techniques such as: IHC-P, ICC, ELISA, Dot.
See all 7-Methylguanosine antibodies

Summary

Host Animal
Mouse
Clone
V2-7673
Antibody Isotype
IgG2a
Application
IHC-P, ICC, ELISA, DB

Basic Information

Immunogen
Carrier protein-conjugated 7-methylguanosine (m7G)-Cap analogue.
Host Species
Mouse
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS pH 7.2, 50% glycerol
Preservative
None
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
7-Methylguanosine
Introduction
7-methylguanosine is an endogenous methylated nucleoside found in human fluids; methylated purine bases are present in higher amounts in tumor-bearing patients compared to healthy controls. DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents. When chemical bonds to DNA, the DNA becomes damaged and proper and complete replication cannot occur to make the normal intended cell. A DNA adduct is an abnormal piece of DNA covalently-bonded to a cancer-causing chemical. This has shown to be the start of a cancerous cell, or carcinogenesis. DNA adducts in scientific experiments are used as bio-markers and as such are themselves measured to reflect quantitatively, for comparison, the amount of cancer in the subject. 7-Methylguanosine is a substrate for purine-nucleoside phosphorylase and Eukaryotic translation initiation factor 4E.
Alternative Names
7-methylguanosine; N7-Methylguanosine; CHEBI:20794; MG7; 2-Amino-6,9-dihydro-7-methyl-6-oxo-9-beta-D-ribofuranosyl-1H-purinium; N7-methyl-guanosine
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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