Sign in or Register   Sign in or Register
  |  

Mouse Anti-AGTR2 Recombinant Antibody (V2-180250) (CBMAB-A1683-YC)

Provided herein is a Mouse monoclonal antibody against Human Angiotensin II Receptor Type 2. The antibody can be used for immunoassay techniques, such as FC, CyTOF.
See all AGTR2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-180250
Antibody Isotype
IgG2b
Application
IHC-F, MC

Basic Information

Immunogen
HEK293 human embryonic kidney cell line transfected with human AGTR-2, Met1-Ser363.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
FC2.5 μg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Angiotensin II Receptor Type 2
Introduction
AGTR2 belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovar
Entrez Gene ID
186
UniProt ID
P50052
Alternative Names
Angiotensin II Receptor Type 2; Angiotensin II Type-2 Receptor; AT2; Type-2 Angiotensin II Receptor; Angiotensin Receptor 2; ATGR2; MRX88;
Function
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
Biological Process
Aldosterone secretion
Blood vessel remodeling
Brain development
Cell growth involved in cardiac muscle cell development
Cell surface receptor signaling pathway
Cellular response to dexamethasone stimulus
Cellular sodium ion homeostasis
cerebellar cortex development
Dopamine biosynthetic process
G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
Inflammatory response
Intracellular signal transduction
Kidney morphogenesis
Negative regulation of blood vessel endothelial cell migration
Negative regulation of cell growth
Negative regulation of fibroblast proliferation
Negative regulation of heart rate
Negative regulation of icosanoid secretion
Negative regulation of neurotrophin TRK receptor signaling pathway
Negative regulation of norepinephrine secretion
Nitric oxide mediated signal transduction
Positive regulation of branching involved in ureteric bud morphogenesis
Positive regulation of cell population proliferation
Positive regulation of extrinsic apoptotic signaling pathway
Positive regulation of nitric oxide biosynthetic process
Positive regulation of nitric-oxide synthase activity
Positive regulation of phosphoprotein phosphatase activity
Positive regulation of renal sodium excretion
Regulation of blood pressure
Regulation of protein import into nucleus
Regulation of systemic arterial blood pressure by circulatory renin-angiotensin
Renin-angiotensin regulation of aldosterone production
Vasodilation
Cellular Location
Cell membrane
Topology
Extracellular: 1-45 aa
Helical: 46-71 aa
Cytoplasmic: 72-80 aa
Helical: 81-102 aa
Extracellular: 103-119 aa
Helical: 120-140 aa
Cytoplasmic: 141-160 aa
Helical: 161-179 aa
Extracellular: 180-208 aa
Helical: 209-234 aa
Cytoplasmic: 235-256 aa
Helical: 257-278 aa
Extracellular: 279-297 aa
Helical: 298-318 aa
Cytoplasmic: 319-363 aa

Laukkanen, L., Diniz, C. R., Foulquier, S., Prickaerts, J., Castrén, E., & Casarotto, P. C. (2021). Facilitation of TRKB activation by the angiotensin II receptor type-2 (AT2R) agonist C21. Pharmaceuticals, 14(8), 773.

Rossi, R. M., Runyon, J., Chawla, M., Miller, D., Forney, C., Chen, X., ... & Muglia, L. (2020). 79: Genetic variants at AGTR2 locus increase risk of preterm birth. American Journal of Obstetrics & Gynecology, 222(1), S66-S67.

Cui, C., Huang, C., Zhou, W., Ji, X., Zhang, F., Wang, L., ... & Cui, Q. (2020). AGTR2, one possible novel key gene for the entry of SARS-CoV-2 into human cells. IEEE/ACM transactions on computational biology and bioinformatics.

Matsushima-Otsuka, S., Fujiwara-Tani, R., Sasaki, T., Ohmori, H., Nakashima, C., Kishi, S., ... & Kuniyasu, H. (2018). Significance of intranuclear angiotensin-II type 2 receptor in oral squamous cell carcinoma. Oncotarget, 9(93), 36561.

Diniz, C. R., Casarotto, P. C., Fred, S. M., Biojone, C., Castrén, E., & Joca, S. R. (2018). Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN. Neuropharmacology, 135, 163-171.

Shepherd, A. J., Mickle, A. D., Golden, J. P., Mack, M. R., Halabi, C. M., De Kloet, A. D., ... & Mohapatra, D. P. (2018). Macrophage angiotensin II type 2 receptor triggers neuropathic pain. Proceedings of the National Academy of Sciences, 115(34), E8057-E8066.

Rathinasabapathy, A., Horowitz, A., Horton, K., Kumar, A., Gladson, S., Unger, T., ... & Shenoy, V. (2018). The selective angiotensin II type 2 receptor agonist, compound 21, attenuates the progression of lung fibrosis and pulmonary hypertension in an experimental model of bleomycin-induced lung injury. Frontiers in physiology, 9, 180.

Özpak, L., Pazarbaşı, A., Keser, N., Yılmaz, M. B., Lüleyap, H. Ü., & Özgünen, F. T. (2017). Evaluation of single nucleotide polymorphisms of angiotensin II type 2 receptor (AGTR2) gene and interleukin 4 (IL-4) gene for their contribution to the risk of preeclampsia in Turkish population. Cukurova Medical Journal, 42(3), 477-483.

Craf, D., Casarotto, P. C., Fred, S. M., Biojone, C., Castrén, E., & Joca, S. R. L. (2017). Antidepressant-like effect of losartan involves TRKB transactivation from angiotensin receptor type 2 (AGTR2) and recruitment of FYN. bioRxiv, 168708.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-AGTR2 Recombinant Antibody (V2-180250)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare