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Mouse Anti-ARHGEF25 Recombinant Antibody (CBLG1-332) (CBMAB-G1277-LY)

This product is antibody recognizes ARHGEF25. The antibody CBLG1-332 immunoassay techniques such as: ELISA (EIA), WB.
See all ARHGEF25 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBLG1-332
Antibody Isotype
IgG1
Application
ELISA, WB, IHC

Basic Information

Immunogen
RhoA/RAC/CDC42 exchange factor.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.3, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Rho Guanine Nucleotide Exchange Factor 25
Introduction
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Entrez Gene ID
Human115557
Mouse52666
Rat314904
UniProt ID
HumanQ86VW2
MouseQ9CWR0
RatQ6P720
Function
May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).
Biological Process
G protein-coupled receptor signaling pathway Source: Reactome
Regulation of Rho protein signal transduction Source: InterPro
Cellular Location
Cell membrane; Sarcomere. Highly colocalizes with actin regions.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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