Mouse Anti-BAZ2B Recombinant Antibody (2D10) (CBMAB-A0721-LY)

The product is antibody recognizes BAZ2B. The antibody 2D10 immunoassay techniques such as: WB, ELISA.
See all BAZ2B antibodies

Published Data

Mouse Anti-BAZ2B Recombinant Antibody (2D10) (CBMAB-A0721-LY) in IF

Colocalization between GPR88 and ATRX, TOP2B, or BAZ2B in cortical neurons. ...View More

Rebeillard, F., De Gois, S., Pietrancosta, N., Mai, T. H., Lai-Kuen, R., Kieffer, B. L., ... & Diaz, J. (2022). The Orphan GPCR Receptor, GPR88, Interacts with Nuclear Protein Partners in the Cerebral Cortex. Cerebral Cortex, 32(3), 479-489.

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2D10

Antibody Isotype

IgG1, κ

Application

WB, ELISA, IHC

Basic Information

Immunogen

BAZ2B (NP_038478.1, 1833 a.a. ~ 1931 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IHC	3 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

bromodomain adjacent to zinc finger domain, 2B

Entrez Gene ID

9031

UniProt ID

Q9UIG0

Alternative Names

DKFZp434H071; DKFZp762I0516; FLJ45644; WALp4

Function

Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI (By similarity) (PubMed:10662543).
Involved in positively modulating the rate of age-related behavioral deterioration (By similarity).
Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1 (By similarity).

Biological Process

Chromatin remodeling Source: BHF-UCL
Modulation of age-related behavioral decline Source: Ensembl
Regulation of transcription by RNA polymerase II Source: BHF-UCL

Cellular Location

Nucleus

References

Scott, T. M., Guo, H., Eichler, E. E., Rosenfeld, J. A., Pang, K., Liu, Z., ... & Scott, D. A. (2020). BAZ2B haploinsufficiency as a cause of developmental delay, intellectual disability, and autism spectrum disorder. Human mutation, 41(5), 921-925.

Dalle Vedove, A., Spiliotopoulos, D., D’Agostino, V. G., Marchand, J. R., Unzue, A., Nevado, C., ... & Caflisch, A. (2018). Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains. ChemMedChem, 13(14), 1479-1487.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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