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Mouse Anti-BLOC1S2 Recombinant Antibody (8C10) (CBMAB-A0800-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
8C10
Antibody Isotype
IgG1, κ
Application
WB, E

Basic Information

Immunogen
BLOC1S2 (NP_776170.2, 1 a.a. ~ 142 a.a) full-length recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
biogenesis of lysosomal organelles complex-1, subunit 2
Introduction
BLOC1S2 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004 [PubMed 15102850]).[supplied by OMIM
Entrez Gene ID
282991
UniProt ID
Q6QNY1
Alternative Names
BLOS2; FLJ30135; MGC10120; RP11-316M21.4
Function
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842).
In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity).
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).
May play a role in cell proliferation (PubMed:15381421).
Biological Process
Anterograde axonal transport Source: UniProtKB
Anterograde synaptic vesicle transport Source: UniProtKB
Endosomal transport Source: GO_Central
Extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
Lysosome localization Source: UniProtKB
Melanosome organization Source: UniProtKB
Microtubule nucleation Source: UniProtKB
Mitochondrial outer membrane permeabilization Source: UniProtKB
Neuron projection development Source: UniProtKB
Platelet dense granule organization Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Cellular Location
Centrosome; Lysosome membrane. Localizes to the centrosomes in a microtubule-dependent manner.
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For research use only. Not intended for any clinical use.

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