Mouse Anti-BLOC1S2 Recombinant Antibody (8C10) (CBMAB-A0800-LY)

Name: Mouse Anti-BLOC1S2 Recombinant Antibody (8C10)
SKU: CBMAB-A0800-LY
Rating: 5 (1 reviews)

See all BLOC1S2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

8C10

Application

WB, E

Immunogen

BLOC1S2 (NP_776170.2, 1 a.a. ~ 142 a.a) full-length recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

biogenesis of lysosomal organelles complex-1, subunit 2

Introduction

BLOC1S2 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004 [PubMed 15102850]).[supplied by OMIM

Entrez Gene ID

282991

UniProt ID

Q6QNY1

Alternative Names

BLOS2; FLJ30135; MGC10120; RP11-316M21.4

Function

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842).
In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity).
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).
May play a role in cell proliferation (PubMed:15381421).

Biological Process

Anterograde axonal transport Source: UniProtKB
Anterograde synaptic vesicle transport Source: UniProtKB
Endosomal transport Source: GO_Central
Extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
Lysosome localization Source: UniProtKB
Melanosome organization Source: UniProtKB
Microtubule nucleation Source: UniProtKB
Mitochondrial outer membrane permeabilization Source: UniProtKB
Neuron projection development Source: UniProtKB
Platelet dense granule organization Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Centrosome; Lysosome membrane. Localizes to the centrosomes in a microtubule-dependent manner.

Cho, H. M., Park, S. J., Choe, S. H., Lee, J. R., Kim, S. U., Jin, Y. B., ... & Huh, J. W. (2019). Cooperative evolution of two different TEs results in lineage-specific novel transcripts in the BLOC1S2 gene. BMC evolutionary biology, 19(1), 1-11.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-BLOC1S2 Recombinant Antibody (8C10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry