BLOC1S2

BLOC1S2 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004 [PubMed 15102850]).[supplied by OMIM

Full Name

biogenesis of lysosomal organelles complex-1, subunit 2

Function

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842).
In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity).
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).
May play a role in cell proliferation (PubMed:15381421).

Biological Process

Anterograde axonal transport Source: UniProtKB
Anterograde synaptic vesicle transport Source: UniProtKB
Endosomal transport Source: GO_Central
Extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
Lysosome localization Source: UniProtKB
Melanosome organization Source: UniProtKB
Microtubule nucleation Source: UniProtKB
Mitochondrial outer membrane permeabilization Source: UniProtKB
Neuron projection development Source: UniProtKB
Platelet dense granule organization Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Centrosome; Lysosome membrane. Localizes to the centrosomes in a microtubule-dependent manner.