Human Recombinant BLOC1S2 protein, GST Tag (V2LY-0526-LY2364)

Name: Human Recombinant BLOC1S2 protein, GST Tag
SKU: V2LY-0526-LY2364
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant BLOC1S2 protein, GST Tag consist of Amino Acid: 1-99 and predicts a molecular mass of 38.7 kDa.

Molecule Mass

38.7 kDa

Sequence

Amino Acid: 1-99

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>74% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

biogenesis of lysosomal organelles complex-1, subunit 2

Function

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842).
In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity).
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).
May play a role in cell proliferation (PubMed:15381421).

Biological Process

Anterograde axonal transport Source: UniProtKB
Anterograde synaptic vesicle transport Source: UniProtKB
Endosomal transport Source: GO_Central
Extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
Lysosome localization Source: UniProtKB
Melanosome organization Source: UniProtKB
Microtubule nucleation Source: UniProtKB
Mitochondrial outer membrane permeabilization Source: UniProtKB
Neuron projection development Source: UniProtKB
Platelet dense granule organization Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB

Cellular Location

Centrosome; Lysosome membrane. Localizes to the centrosomes in a microtubule-dependent manner.

Cho, H. M., Park, S. J., Choe, S. H., Lee, J. R., Kim, S. U., Jin, Y. B., ... & Huh, J. W. (2019). Cooperative evolution of two different TEs results in lineage-specific novel transcripts in the BLOC1S2 gene. BMC evolutionary biology, 19(1), 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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