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Mouse Anti-BMP5 Recombinant Antibody (CBYY-1995) (CBMAB-2344-YY)

This product is mouse antibody that recognizes BMP5. The antibody CBYY-1995 can be used for immunoassay techniques such as: ELISA
See all BMP5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-1995
Antibody Isotype
IgG2a, κ
Application
E

Basic Information

Immunogen
BMP5 (NP_066551.1, 341 a.a. ~ 440 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Bone Morphogenetic Protein 5
Introduction
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in Bovinene and cartilage development. PolymorphisMouse in this gene may be associated with osteoarthritis in human patients. This gene is differentially regulated in multiple human cancers. This gene encodes distinct protein isoforMouse that may be similarly proteolytically processed.
Entrez Gene ID
653
UniProt ID
P22003
Alternative Names
Bovinene Morphogenetic Protein 5; BMP-5;
Function
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:11580864, PubMed:29321139).
Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:11580864).
In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:29321139, PubMed:11580864).
Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed:20402566).
Biological Process
Allantois development Source: BHF-UCL
BMP signaling pathway Source: GO_Central
Cardiac muscle tissue development Source: BHF-UCL
Cardiac septum morphogenesis Source: BHF-UCL
Cartilage development Source: UniProtKB-KW
Chorio-allantoic fusion Source: BHF-UCL
Endocardial cushion formation Source: BHF-UCL
Heart trabecula morphogenesis Source: BHF-UCL
Hindbrain development Source: BHF-UCL
Negative regulation of aldosterone biosynthetic process Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of cortisol biosynthetic process Source: BHF-UCL
Negative regulation of epithelial to mesenchymal transition Source: BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
Negative regulation of insulin-like growth factor receptor signaling pathway Source: BHF-UCL
Negative regulation of mononuclear cell migration Source: BHF-UCL
Negative regulation of steroid biosynthetic process Source: BHF-UCL
Neural fold elevation formation Source: BHF-UCL
Ossification Source: UniProtKB-KW
Pericardium morphogenesis Source: BHF-UCL
Pharyngeal system development Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of dendrite development Source: BHF-UCL
Positive regulation of epithelial cell proliferation Source: BHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Skeletal system development Source: UniProtKB
SMAD protein signal transduction Source: GO_Central
Type B pancreatic cell development Source: BHF-UCL
Cellular Location
Secreted

Qiu, Y. Y., Zhang, H. S., Tang, Y., Liu, F. Y., Pang, J. Q., Zhang, X. Y., ... & Chen, S. J. (2021). Mitochondrial dysfunction resulting from the down-regulation of bone morphogenetic protein 5 may cause microtia. Annals of Translational Medicine, 9(5).

Karim, M., Samad, A., Adhikari, U. K., Kader, M., Kabir, M., Islam, M., & Hasan, M. (2020). A multi-omics analysis of bone morphogenetic protein 5 (BMP5) mRNA expression and clinical prognostic outcomes in different cancers using bioinformatics approaches. Biomedicines, 8(2), 19.

Mu, F. S., Chen, M., Tian, M. F., Feng, C. Y., Meng, X. M., & Luo, M. (2020). Effect of Boschniakia Rossica Extract on BMP-5 and ActRIIA in Mice Model of Kidney-Yang Deficient.

Gjelsvik, K. J., Follansbee, T. L., & Ganter, G. K. (2018). Bone Morphogenetic Protein Glass Bottom Boat (BMP5/6/7/8) and its receptor Wishful Thinking (BMPRII) are required for injury-induced allodynia in Drosophila. Molecular pain, 14, 1744806918802703.

Mausner-Fainberg, K., Golan, M., & Karni, A. (2017). Sera of relapsing-remitting multiple sclerosis (RRMS) patients express high levels of bone morphogenetic protein-2 that correlate with BMP-4 and BMP-5 levels, and induce low neuronal phenotype in vitro (P1. 387).

Vijayan, V., Gupta, S., & Gupta, S. (2017). Bone morphogenetic protein‐5, a key molecule that mediates differentiation in MC3T3E1 osteoblast cell line. Biofactors, 43(4), 558-566.

Sharma, A. C., Srivastava, R. N., Srivastava, S. R., Agrahari, A., Singh, A., & Parmar, D. (2017). Evaluation of the association between a single-nucleotide polymorphism of bone morphogenetic proteins 5 gene and risk of knee osteoarthritis. Journal of postgraduate medicine, 63(3), 151.

Penn, M., Mausner-Fainberg, K., Golan, M., & Karni, A. (2017). High serum levels of BMP-2 correlate with BMP-4 and BMP-5 levels and induce reduced neuronal phenotype in patients with relapsing-remitting multiple sclerosis. Journal of neuroimmunology, 310, 120-128.

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For research use only. Not intended for any clinical use.

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