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Mouse Anti-BTN3A1 Recombinant Antibody (849203) (CBMAB-C8980-LY)

This product is antibody recognizes BTN3A1. The antibody 849203 immunoassay techniques such as: FC, CyTOF.
See all BTN3A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
849203
Antibody Isotype
IgG1
Application
FC, CyTOF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Butyrophilin Subfamily 3 Member A1
Introduction
The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]
Entrez Gene ID
11119
UniProt ID
O00481
Alternative Names
Butyrophilin Subfamily 3 Member A1; BTF5; DJ45P21.3 (Butyrophilin, Subfamily 3, Member A1); Butyrophilin, Subfamily 3, Member A1; CD277 Antigen; BTN3.1; BT3.1; CD277;
Function
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.
Biological Process
Activated T cell proliferation Source: UniProtKB
Adaptive immune response Source: Reactome
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of interferon-gamma production Source: UniProtKB
Regulation of cytokine production Source: GO_Central
T cell receptor signaling pathway Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 30-254 aa
Helical: 255-271 aa
Cytoplasmic: 272-513 aa
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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