Sign in or Register   Sign in or Register
  |  

Rabbit Anti-CACNA2D4 Recombinant Antibody (EG453) (CBMAB-EN513-LY)

The product is antibody recognizes CACNA2D4 . The antibody EG453 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all CACNA2D4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG453
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CACNA2D4.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 4
Introduction
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human93589
Mouse319734
Rat312668
UniProt ID
HumanQ7Z3S7
MouseQ5RJF7
RatP22002
Alternative Names
Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 4; Calcium Channel, Voltage-Dependent, Alpha 2/Delta Subunit 4; Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-4; Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-4; Voltage-Gated Calcium Channel Alpha(2)Delta-4 Subunit; RCD4;
Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.
Biological Process
Calcium ion transmembrane transport Source: UniProtKB
Detection of light stimulus involved in visual perception Source: UniProtKB
Regulation of ion transmembrane transport Source: UniProtKB-KW
Cellular Location
Membrane
Involvement in disease
Retinal cone dystrophy 4 (RCD4): Characterized by minimal symptoms except for slowly progressive reduction in visual acuity.
Topology
Extracellular: 20-1115 aa
Helical: 1116-1136 aa
Cytoplasmic: 1137 aa
PTM
May be proteolytically processed into subunits alpha-2-4 and delta-4 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity).
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-CACNA2D4 Recombinant Antibody (EG453)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare