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Mouse Anti-Cactus Recombinant Antibody (3H12) (CBMAB-0492-LY)

This product is mouse antibody recognizes cactus of drosophila. The antibody 3H12 immunoassay techniques such as: IF, WB, IP.
See all Cactus antibodies

Summary

Host Animal
Mouse
Specificity
Common fruit fly
Clone
3H12
Antibody Isotype
IgG1
Application
IF, WB, IP

Basic Information

Immunogen
Recombinant peptide (Full Length)
Specificity
Common fruit fly
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cactus
Introduction
Involved in the formation of the dorsoventral pattern. It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo. Acts as a negative regulator of the NF-kappa-B (rel) signaling pathway. Cact is degraded by ird5, this is essential for NF-kappa-B (rel) activation.
Entrez Gene ID
34969
UniProt ID
Q03017
Alternative Names
CG5848; cac; dip6; IkappaB
Function
Involved in the formation of the dorsoventral pattern. It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo. Acts as a negative regulator of the NF-kappa-B (rel) signaling pathway. Cact is degraded by IKKbeta, this is essential for NF-kappa-B (rel) activation.
Biological Process
Antimicrobial humoral response Source: FlyBase
Cytoplasmic sequestering of NF-kappaB Source: FlyBase
Dorsal/ventral axis specification Source: UniProtKB
Dorsal/ventral pattern formation Source: FlyBase
Dorsal appendage formation Source: FlyBase
Negative regulation of antifungal peptide production Source: FlyBase
Negative regulation of hemocyte differentiation Source: FlyBase
Negative regulation of Toll signaling pathway Source: FlyBase
Nervous system development Source: FlyBase
Oogenesis Source: FlyBase
Cellular Location
Cytoplasm
PTM
Activated IKKbeta phosphorylates cact.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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