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Rabbit Anti-CADM2 Recombinant Antibody (EG458) (CBMAB-EN518-LY)

The product is antibody recognizes CADM2 . The antibody EG458 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all CADM2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG458
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CADM2.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cell Adhesion Molecule 2
Introduction
CADM2 (Cell Adhesion Molecule 2) is a Protein Coding gene. Among its related pathways are Cell junction organization. An important paralog of this gene is CADM3.
Entrez Gene ID
Human253559
Mouse239857
Rat360687
UniProt ID
HumanQ8N3J6
MouseQ8BLQ9
RatQ1WIM2
Alternative Names
Cell Adhesion Molecule 2; Immunoglobulin Superfamily Member 4D; Synaptic Cell Adhesion Molecule 2; Nectin-Like Protein 3; Nectin-Like 3; SynCAM 2;
Function
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.
Biological Process
Adherens junction organization Source: Reactome
Cell adhesion Source: UniProtKB-KW
Cellular Location
Cell membrane; Synapse; Axon. Found in the axoplasm of myelinated axons.
Topology
Extracellular: 25-367 aa
Helical: 368-388 aa
Cytoplasmic: 389-435 aa

Dai, L., Li, Y. H., Liang, Y. Y., Zhao, J., Chen, G., Yin, J., ... & Long, H. D. (2021). High expression of cell adhesion molecule 2 unfavorably impacts survival in non-small cell lung cancer patients with brain metastases. Journal of Thoracic Disease, 13(4), 2437.

Dai, L., Zhao, J., Yin, J., Fu, W., & Chen, G. (2020). Cell adhesion molecule 2 (CADM2) promotes brain metastasis by inducing epithelial-mesenchymal transition (EMT) in human non-small cell lung cancer. Annals of translational medicine, 8(7).

Liu, N., Yang, C., Bai, W., Wang, Z., Wang, X., Johnson, M., ... & Tu, Y. (2019). CADM2 inhibits human glioma proliferation, migration and invasion. Oncology reports, 41(4), 2273-2280.

Greenbaum, L., Ravona-Springer, R., Livny, A., Shelly, S., Sharvit-Ginon, I., Ganmore, I., ... & Schnaider Beeri, M. (2019). The CADM2 gene is associated with processing speed performance–evidence among elderly with type 2 diabetes. The World Journal of Biological Psychiatry, 20(7), 577-583.

Li, X., Chen, D., Li, M., Gao, X., Shi, G., & Zhao, H. (2018). The CADM2/Akt pathway is involved in the inhibitory effect of miR-21-5p downregulation on proliferation and apoptosis in esophageal squamous cell carcinoma cells. Chemico-biological interactions, 288, 76-82.

Yan, X., Wang, Z., Schmidt, V., Gauert, A., Willnow, T. E., Heinig, M., & Poy, M. N. (2018). Cadm2 regulates body weight and energy homeostasis in mice. Molecular metabolism, 8, 180-188.

Yang, L., Zhao, G., Wang, F., Li, C., & Wang, X. (2018). Hypoxia-regulated miR-146a targets cell adhesion molecule 2 to promote proliferation, migration, and invasion of clear cell renal cell carcinoma. Cellular Physiology and Biochemistry, 49(3), 920-931.

Huang, Y. X., Nie, X. G., Li, G. D., Fan, D. S., Song, L. L., & Zhang, X. L. (2018). Downregulation of microRNA‑182 inhibits cell viability, invasion and angiogenesis in retinoblastoma through inhibition of the PI3K/AKT pathway and CADM2 upregulation. International journal of oncology, 53(6), 2615-2626.

Li, D., Zhang, Y., Zhang, H., Zhan, C., Li, X., Ba, T., ... & Gao, X. (2018). CADM2, as a new target of miR-10b, promotes tumor metastasis through FAK/AKT pathway in hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research, 37(1), 1-11.

Liu, Y., Li, Y., Ren, Z., Si, W., Li, Y., Wei, G., ... & Chen, D. (2017). MicroRNA-125a-3p is involved in early behavioral disorders in stroke-afflicted rats through the regulation of Cadm2. International journal of molecular medicine, 40(6), 1851-1859.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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