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Mouse Anti-CadN Antibody (DN-Ex #8) (CBMAB-1043CQ)

This product is a mouse antibody that recognizes CadN. The antibody DN-Ex #8 can be used for immunoassay techniques such as: IF, IHC, WB.
See all CadN antibodies

Summary

Host Animal
Mouse
Specificity
Common fruit fly
Clone
DN-Ex #8
Antibody Isotype
IgG2a
Application
IF, IHC, WB

Basic Information

Immunogen
Recombinant fusion protein containing the extracellular region of N-cadherin from cadherin repeats 2 to 8
Specificity
Common fruit fly
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Extracellular region including CR2-CR8

Target

Full Name
cadherin, DN- (extracellular domain)
Introduction
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information.
Entrez Gene ID
35070
UniProt ID
O15943
Alternative Names
Neural-cadherin
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May associate with arm neural isoform and participate in the transmission of developmental information.
Biological Process
Axonal fasciculation Source: FlyBase
Axon extension Source: FlyBase
Axon extension involved in axon guidance Source: FlyBase
Axon guidance Source: FlyBase
Axon target recognition Source: FlyBase
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
Cell-cell adhesion Source: GO_Central
Cell-cell adhesion mediated by cadherin Source: FlyBase
Homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
Negative regulation of dendrite morphogenesis Source: FlyBase
Ommatidial rotation Source: FlyBase
R7 cell development Source: FlyBase
R8 cell development Source: FlyBase
Regulation of axon extension involved in axon guidance Source: FlyBase
Regulation of dendrite morphogenesis Source: FlyBase
Retinal ganglion cell axon guidance Source: FlyBase
Cellular Location
Cell membrane
Topology
Extracellular: ?-2916 aa
Helical: 2917-2937 aa
Cytoplasmic: 2938-3097 aa

Zhang, L., Ma, L., Li, J., Lei, J., Chen, J., & Yu, C. (2021). VE‐cadherin N‐glycosylation modified by GnT‐V regulates VE‐cadherin/β‐catenin interaction and monocyte adhesion. Experimental Physiology.

Jang, N. R., Choi, J. H., & Gu, M. J. (2021). Aberrant Expression of E-cadherin, N-cadherin, and P-cadherin in Clear Cell Renal Cell Carcinoma: Association With Adverse Clinicopathologic Factors and Poor Prognosis. Applied Immunohistochemistry & Molecular Morphology, 29(3), 223-230.

Zeng, C., Sun, B., Cao, X., Zhu, H., Oluwadahunsi, O. M., Liu, D., ... & Wang, P. G. (2020). Chemical Synthesis of Homogeneous Human E-Cadherin N-Linked Glycopeptides: Stereoselective Convergent Glycosylation and Chemoselective Solid-Phase Aspartylation. Organic Letters, 22(21), 8349-8353.

Puchinskaya, M. (2019). Patterns of N-cadherin (N-cad) and vimentin (Vim) expression as a sign of epithelial-mesenchymal transition (EMT) in prostate cancer (PCa). Annals of Oncology, 30, vii11.

Liao, S., Yu, C., Liu, H., Zhang, C., Li, Y., & Zhong, X. (2019). Long non-coding RNA H19 promotes the proliferation and invasion of lung cancer cells and regulates the expression of E-cadherin, N-cadherin, and vimentin. OncoTargets and therapy, 12, 4099.

Guo, M., Mu, Y., Yu, D., Li, J., Chen, F., Wei, B., ... & Liang, F. (2018). Comparison of the expression of TGF‑β1, E‑cadherin, N‑cadherin, TP53, RB1CC1 and HIF‑1α in oral squamous cell carcinoma and lymph node metastases of humans and mice. Oncology letters, 15(2), 1639-1645.

Labernadie, A., Kato, T., Brugués, A., Serra-Picamal, X., Derzsi, S., Arwert, E., ... & Trepat, X. (2017). A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion. Nature cell biology, 19(3), 224-237.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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