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Mouse Anti-CALB1 Recombinant Antibody (AF2E5) (CBMAB-1270-CN)

This product is a mouse antibody that recognizes CALB1 of human. The antibody AF2E5 can be used for immunoassay techniques such as: FC, IF, WB, ELISA.
See all CALB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
AF2E5
Antibody Isotype
IgG2a, Κ
Application
FC, IF, WB, ELISA

Basic Information

Immunogen
Recombinant full length Human Calbindin protein with a His tag (His-Calbindin) purified from E. coli
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol, 0.01% BSA, HEPES, 0.15M Sodium chloride
Preservative
0.03% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Calbindin 1
Introduction
The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. The protein may stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
Entrez Gene ID
Human793
Mouse12307
Rat83839
UniProt ID
HumanP05937
MouseP12658
RatP07171
Alternative Names
CALB; D-28K
Function
Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
Biological Process
Amyloid fibril formation Source: Reactome
Cellular response to organic substance Source: Ensembl
Cochlea development Source: Ensembl
Locomotory behavior Source: Ensembl
Long-term memory Source: UniProtKB
Metanephric collecting duct development Source: Ensembl
Metanephric connecting tubule development Source: Ensembl
Metanephric distal convoluted tubule development Source: Ensembl
Metanephric part of ureteric bud development Source: Ensembl
Regulation of cytosolic calcium ion concentration Source: GO_Central
Regulation of long-term synaptic potentiation Source: GO_Central
Regulation of presynaptic cytosolic calcium ion concentration Source: GO_Central
Retina layer formation Source: Ensembl
Short-term memory Source: UniProtKB
Cellular Location
Cuticular plate; Cytosol; Postsynaptic cytosol; Presynaptic cytosol; Extracellular exosome; Nucleus; Axon; Calyx of Held; Dendrite; Dendritic spine; GABA-ergic synapse; Glutamatergic synapse; Hippocampal mossy fiber to CA3 synapse; Neuron projection; Neuronal cell body; Stereocilium; Synapse; Terminal bouton
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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