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Rabbit Anti-CALM3 Recombinant Antibody (CBLC289-LY) (CBMAB-C9654-LY)

The product is antibody recognizes CALM3. The antibody CBLC289-LY immunoassay techniques such as: WB, IP, FC.
See all CALM3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBLC289-LY
Antibody Isotype
IgG
Application
WB, IP, FC

Basic Information

Immunogen
A synthetic peptide corresponding to residues at the N-terminus of human Calmodulin (CaM) was used as an immunogen
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.05% BSA, 50% Glycerol
Preservative
0.01% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
calmodulin 3 (phosphorylase kinase, delta)
Introduction
This gene encodes a member of a family of proteins that binds calcium and functions as a enzymatic co-factor. Activity of this protein is important in the regulation of the cell cycle and cytokinesis. Multiple alternatively spliced transcript variants have been observed at this gene. [provided by RefSeq, Aug 2016]
Entrez Gene ID
Human808
Mouse12315
Rat24244
UniProt ID
HumanP0DP25
MouseP0DP28
RatP0DP31
Alternative Names
Calmodulin 3; Phosphorylase Kinase Subunit Delta; Prepro-Calmodulin 3; CaMIII; Calmodulin 3 (Phosphorylase Kinase, Delta); Epididymis Secretory Protein Li 72; Calmodulin-3; HEL-S-72;
Function
Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Is a regulator of voltage-dependent L-type calcium channels (PubMed:31454269).
Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
Biological Process
Activation of adenylate cyclase activity Source: Ensembl
Detection of calcium ion Source: BHF-UCL
Establishment of protein localization to mitochondrial membrane Source: Ensembl
G2/M transition of mitotic cell cycle Source: Ensembl
G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of high voltage-gated calcium channel activity Source: UniProtKB
Negative regulation of peptidyl-threonine phosphorylation Source: BHF-UCL
Negative regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Positive regulation of cyclic-nucleotide phosphodiesterase activity Source: BHF-UCL
Positive regulation of DNA binding Source: Ensembl
Positive regulation of nitric-oxide synthase activity Source: Ensembl
Positive regulation of peptidyl-threonine phosphorylation Source: BHF-UCL
Positive regulation of phosphoprotein phosphatase activity Source: BHF-UCL
Positive regulation of protein autophosphorylation Source: BHF-UCL
Positive regulation of protein dephosphorylation Source: BHF-UCL
Positive regulation of protein serine/threonine kinase activity Source: BHF-UCL
Positive regulation of ryanodine-sensitive calcium-release channel activity Source: BHF-UCL
Regulation of cardiac muscle cell action potential Source: UniProtKB
Regulation of cardiac muscle contraction Source: BHF-UCL
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion Source: BHF-UCL
Regulation of cell communication by electrical coupling involved in cardiac conduction Source: BHF-UCL
Regulation of cytokinesis Source: UniProtKB
Regulation of heart rate Source: BHF-UCL
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: BHF-UCL
Regulation of synaptic vesicle endocytosis Source: Ensembl
Regulation of synaptic vesicle exocytosis Source: Ensembl
Response to amphetamine Source: Ensembl
Response to calcium ion Source: BHF-UCL
Response to corticosterone Source: Ensembl
Substantia nigra development Source: UniProtKB
Cellular Location
Spindle; Spindle pole; Centrosome. Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
Involvement in disease
Ventricular tachycardia, catecholaminergic polymorphic, 6 (CPVT6): An arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Patients present with recurrent syncope, seizures, or sudden death after physical activity or emotional stress. CPVT6 inheritance is autosomal dominant.
Long QT syndrome 16 (LQT16): An autosomal dominant form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
PTM
Ubiquitination results in a strongly decreased activity.
Phosphorylation results in a decreased activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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