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Mouse Anti-CAMK2G Recombinant Antibody (6G9) (CBMAB-C1682-YY)

This product is mouse antibody that recognizes CAMK2G. The antibody 6G9 can be used for immunoassay techniques such as: WB, IP, ELISA, IHC-P, RIA, IHC-Fr, IF
See all CAMK2G antibodies
Published Data
Fig.1 Autoradiogram showing the reaction of antibody 6G9 with "phospho" and "dephospho" forms of the a-subunit Pure kinase was autophosphorylated for the lengths of time indicated.
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Fig.2 c-Fos expression in CaMKIIα+ pyramidal cells following SD and SR.
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Summary

Host Animal
Mouse
Specificity
Rat
Clone
6G9
Antibody Isotype
IgG1
Application
WB, IP, ELISA, IHC-P, RIA, IHC-Fr, IF

Basic Information

Immunogen
Detects approx. 50-60kDa protein, corresponding to the molecular mass of CaMKII alpha-subunit on SDS page immunoblots. Recognizes both phosphorylated and non-phosphorylated forms.Partially purified rat CaMKII
Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Buffer
1 mg/mL
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Calcium/Calmodulin Dependent Protein Kinase II Gamma
Entrez Gene ID
171140
UniProt ID
P11730
Function
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca2+ transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290).
It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
Biological Process
Cell differentiation Source: UniProtKB-KW
Insulin secretion Source: UniProtKB
Interferon-gamma-mediated signaling pathway Source: Reactome
Nervous system development Source: UniProtKB-KW
Regulation of calcium ion transport Source: UniProtKB
Regulation of cellular response to heat Source: Reactome
Regulation of neuron projection development Source: UniProtKB
Regulation of skeletal muscle adaptation Source: UniProtKB
Cellular Location
Sarcoplasmic reticulum membrane
Involvement in disease
Intellectual developmental disorder, autosomal dominant 59 (MRD59): An autosomal dominant form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
PTM
Autophosphorylation of Thr-287 following activation by Ca2+/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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