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Human Anti-CAMK2N1 Recombinant Antibody (CBYY-C0915) (CBMAB-C2352-YY)

This product is human antibody that recognizes CAMK2N1. The antibody CBYY-C0915 can be used for immunoassay techniques such as: IHC-Fr
See all CAMK2N1 antibodies

Summary

Host Animal
Human
Specificity
Rat, Mouse
Clone
CBYY-C0915
Application
IHC-Fr

Basic Information

Immunogen
Peptide sequence C-DEKLSPYGDGGDVGQI that corresponds to amino acids 10-25 of mouse calcium/calmodulin-dependent protein kinase II inhibitor 1 (CaMK II N alpha)
Specificity
Rat, Mouse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
0.1 mg/mL
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 1
Entrez Gene ID
Mouse66259
Rat287005
UniProt ID
MouseQ6QWF9
RatQ9JI15
Alternative Names
Capping Actin Protein Of Muscle Z-Line Beta Subunit; Capping Protein (Actin Filament) Muscle Z-Line, Beta; CapZ Beta; F-Actin-Capping Protein Subunit Beta; CAPPB; CAPZ; CAPB;
Function
Potent and specific inhibitor of CaM-kinase II (CAMK2).
Biological Process
Calcium ion homeostasis Source: Ensembl
Negative regulation of cell cycle Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of cyclin-dependent protein kinase activity Source: UniProtKB
Negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
Negative regulation of protein kinase activity Source: UniProtKB
Negative regulation of proteolysis Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Positive regulation of systemic arterial blood pressure Source: Ensembl
Cellular Location
Synaptosome; Postsynaptic density

Peng, J. M., Tseng, R. H., Shih, T. C., & Hsieh, S. Y. (2021). CAMK2N1 suppresses hepatoma growth through inhibiting E2F1-mediated cell-cycle signaling. Cancer letters, 497, 66-76.

Heinze, K., Rengsberger, M., Gajda, M., Jansen, L., Osmers, L., Oliveira-Ferrer, L., ... & Runnebaum, I. B. (2021). CAMK2N1/RUNX3 methylation is an independent prognostic biomarker for progression-free and overall survival of platinum-sensitive epithelial ovarian cancer patients. Clinical Epigenetics, 13(1), 1-13.

Wei, Z., Fei, Y., Wang, Q., Hou, J., Cai, X., Yang, Y., ... & Li, Y. G. (2021). Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation. Free Radical Biology and Medicine, 167, 243-257.

Astudillo, D., Karmelic, D., Casas, B. S., Otmakhov, N., Palma, V., & Sanhueza, M. (2020). CaMKII inhibitor 1 (CaMK2N1) mRNA is upregulated following LTP induction in hippocampal slices. Synapse, 74(10), e22158.

Wu, C., Miao, C., Tang, Q., Zhou, X., Xi, P., Chang, P. A., ... & Ni, H. (2020). MiR‐129‐5p promotes docetaxel resistance in prostate cancer by down‐regulating CAMK2N1 expression. Journal of cellular and molecular medicine, 24(3), 2098-2108.

Xu, K., Hu, X., Sun, L., Liang, Q., Ouyang, G., Zhang, Y., ... & Yan, X. (2019). MicroRNA-532 exerts oncogenic functions in t (4; 14) multiple myeloma by targeting CAMK2N1. Human cell, 32(4), 529-539.

Alfazema, N., Barrier, M., de Procé, S. M., Menzies, R. I., Carter, R., Stewart, K., ... & Coan, P. M. (2019). Camk2n1 is a negative regulator of blood pressure, left ventricular mass, insulin sensitivity, and promotes adiposity. Hypertension, 74(3), 687-696.

Carneiro, I., Quintela-Vieira, F., Lobo, J., Moreira-Barbosa, C., Menezes, F. D., Martins, A. T., ... & Henrique, R. (2019). Expression of EMT-related genes CAMK2N1 and WNT5A is increased in locally invasive and metastatic prostate cancer. Journal of Cancer, 10(24), 5915.

Li, N., Nan, C. C., Zhong, X. Y., Weng, J. Q., Fan, H. D., Sun, H. P., ... & Huang, S. X. (2018). miR-182-5p promotes growth in oral squamous cell carcinoma by inhibiting CAMK2N1. Cellular Physiology and Biochemistry, 49(4), 1329-1341.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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