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Mouse Anti-CASP8 Recombinant Antibody (FLICE 4-1-20) (CBMAB-C5385-CQ)

This product is a mouse antibody that recognizes CASP8. The antibody FLICE 4-1-20 can be used for immunoassay techniques such as: WB.
Host Animal
Mouse
Application
WB
Immunogen
Full length recombinant human Caspase 8 [UniProt# Q14790]
Antibody Isotype
IgG1, κ
Cross Reactivity
Human
Clone
FLICE 4-1-20
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Introduction
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
Alternative Name
Caspase 8; Caspase 8, Apoptosis-Related Cysteine Peptidase; Caspase 8, Apoptosis-Related Cysteine Protease; MORT1-Associated Ced-3 Homolog; ICE-Like Apoptotic Protease 5; Apoptotic Cysteine Protease; Apoptotic Protease Mch-5; FADD-Like ICE; Casp-8; FLICE; CAP4;
Entrez Gene ID
UniProt ID
Cat CBMAB-C5385-CQ
Conjugates
Size
Price $
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