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Mouse Anti-CCNG1 Recombinant Antibody (11C8) (CBMAB-C2492-LY)

This product is antibody recognizes CCNG1. The antibody 11C8 immunoassay techniques such as: WB, IHC-P.
See all CCNG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
11C8
Antibody Isotype
IgG2b
Application
WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
cyclin G1
Introduction
CCNG1 (Cyclin G1) is a Protein Coding gene. Diseases associated with CCNG1 include Mantle Cell Lymphoma and Osteogenic Sarcoma. Among its related pathways are Gene Expression and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include protein domain specific binding. An important paralog of this gene is CCNG2.
Entrez Gene ID
900
UniProt ID
P51959
Alternative Names
Cyclin G1; Cyclin-G; CCNG; Cyclin-G1; CYCG1;
Function
May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity).
Biological Process
Cell division Source: UniProtKB-KW
Mitotic cell cycle phase transition Source: GO_Central
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of signal transduction by p53 class mediator Source: Reactome
Cellular Location
Nucleus. DNA replication foci after DNA damage.

Ravicz, J., Szeto, C., Reddy, S., Chawla, S., Morse, M., & Gordon, E. (2021). Enhanced expression of human cyclin G1 (CCNG1) in tumors, a novel biomarker in development for cancer therapy/gene therapy.

Liu, Y., Fu, X., Wang, X., Liu, Y., & Song, X. (2021). Long non‑coding RNA OIP5‑AS1 facilitates the progression of ovarian cancer via the miR‑128‑3p/CCNG1 axis. Molecular medicine reports, 23(5), 1-12.

Xu, Y., Zhang, Q., Miao, C., Dongol, S., Li, Y., Jin, C., ... & Kong, B. (2019). CCNG1 (Cyclin G1) regulation by mutant‐P53 via induction of Notch3 expression promotes high‐grade serous ovarian cancer (HGSOC) tumorigenesis and progression. Cancer medicine, 8(1), 351-362.

Gordon, E. M., Szeto, C., Ravicz, J. R., Reddy, S., Morse, M., Chawla, S., & Hall, F. (2019). Enhanced expression of human cyclin G1 (CCNG1) gene in metastatic cancer, a novel biomarker in development for CCNG1 inhibitor therapy.

Yin, J. J., & Cheng, X. Y. (2019). MicroRNA-23a inhibits the growth of papillary thyroid carcinoma via regulating cyclin G1. Eur Rev Med Pharmacol Sci, 23(8), 3431-9.

Li, C., Hu, G., Wei, B., Wang, L., & Liu, N. (2019). lncRNA LINC01494 promotes proliferation, migration and invasion in glioma through miR-122-5p/CCNG1 Axis. OncoTargets and therapy, 12, 7655.

Dy, P. S. G., Chawla, S. P., Hall, F. L., & Gordon, E. M. (2018). Immune cell trafficking in the tumor microenvironment of human cyclin G1 (CCNG1) inhibitor-treated tumors. Br. J. Cancer Res, 1, 202-207.

Ravicz, J., Liu, S., Andrali, S. S., Reddy, S. K., Sellappan, S., Leong, B., ... & Gordon, E. M. (2018). Differential expression of human cyclin G1 (CCNG1) in cancer: A novel biomarker in development for CCNG1 inhibitor therapy.

Yeh, T. H., Liu, H. F., Li, Y. W., Lu, C. S., Shih, H. Y., Chiu, C. C., ... & Cheng, Y. C. (2018). C9orf72 is essential for neurodevelopment and motility mediated by Cyclin G1. Experimental Neurology, 304, 114-124.

Gordon, E. M., Ravicz, J. R., Liu, S., Chawla, S. P., & Hall, F. L. (2018). Cell cycle checkpoint control: The cyclin G1/Mdm2/p53 axis emerges as a strategic target for broad‑spectrum cancer gene therapy-A review of molecular mechanisms for oncologists. Molecular and clinical oncology, 9(2), 115-134.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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