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Rabbit Anti-CCT6A Recombinant Antibody (EG528) (CBMAB-EN601-LY)

The product is antibody recognizes CCT6A . The antibody EG528 immunoassay techniques such as: WB: 1:500~1:3000 IHC: 1:50~1:100 ELISA: 1:10000.
See all CCT6A antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG528
Antibody Isotype
IgG
Application
WB: 1:500~1:3000 IHC: 1:50~1:100 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CCT6A.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chaperonin Containing TCP1 Subunit 6A
Introduction
CCT6A (Chaperonin Containing TCP1 Subunit 6A) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding. Gene Ontology (GO) annotations related to this gene include unfolded protein binding. An important paralog of this gene is CCT6B.
Entrez Gene ID
Human908
Mouse12466
Rat288620
UniProt ID
HumanP40227
MouseP80317
RatQ3MHS9
Alternative Names
Chaperonin Containing TCP1 Subunit 6A; Chaperonin Containing TCP1, Subunit 6A (Zeta 1); CCT-Zeta-1; TCP-1-Zeta; TCP20; Cctz; CCT6; HTR3; Acute Morphine Dependence Related Protein 2; Acute Morphine Dependence-Related Protein 2;
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444).
The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444).
The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Biological Process
Positive regulation of establishment of protein localization to telomere Source: BHF-UCL
Positive regulation of protein localization to Cajal body Source: BHF-UCL
Positive regulation of telomerase RNA localization to Cajal body Source: BHF-UCL
Positive regulation of telomere maintenance via telomerase Source: BHF-UCL
Protein folding Source: FlyBase
Protein stabilization Source: BHF-UCL
Cellular Location
Cytoplasm

Sun, H., Wang, Y., Jing, H. Y., Yang, X. Y., Shi, X. X., Zhang, J. H., ... & Yu, L. (2021). Chaperonin-Containing TCP1 Subunit 6A Is a Prognostic Potential Biomarker That Correlates With the Presence of Immune Infiltrates in Colorectal Cancer. Frontiers in Genetics, 12, 556.

Cai, Y., Wu, D., & Zhan, L. (2021). CCT6A expression in hepatocellular carcinoma and its correlation with clinical characteristics, liver function indexes, tumor markers and prognosis. Clinics and Research in Hepatology and Gastroenterology, 101796.

Ma, J., Yang, L., Feng, H., Zheng, L., Meng, H., & Li, X. (2021). CCT6A may act as a potential biomarker reflecting tumor size, lymphatic metastasis, FIGO stage, and prognosis in cervical cancer patients. Journal of clinical laboratory analysis, 35(8), e23793.

Jiang, J., Liu, C., Xu, G., Liang, T., Yu, C., Liao, S., ... & Zhan, X. (2021). CCT6A, a novel prognostic biomarker for Ewing sarcoma. Medicine, 100(4).

Zhang, T., Shi, W., Tian, K., & Kong, Y. (2020). Chaperonin containing t-complex polypeptide 1 subunit 6A correlates with lymph node metastasis, abnormal carcinoembryonic antigen and poor survival profiles in non-small cell lung carcinoma. World journal of surgical oncology, 18(1), 1-10.

Li, B., Lu, X., Ma, C., Sun, S., Shu, X., Wang, Z., & Sun, W. (2020). Long non-coding RNA NEAT1 promotes human glioma tumor progression via miR-152-3p/CCT6A pathway. Neuroscience Letters, 732, 135086.

Hallal, S., Russell, B. P., Wei, H., Lee, M. Y. T., Toon, C. W., Sy, J., ... & Kaufman, K. L. (2019). Extracellular vesicles from neurosurgical aspirates identifies chaperonin containing TCP1 subunit 6A as a potential glioblastoma biomarker with prognostic significance. Proteomics, 19(1-2), 1800157.

Huang, K., Zeng, Y., Xie, Y., Huang, L., & Wu, Y. (2019). Bioinformatics analysis of the prognostic value of CCT6A and associated signalling pathways in breast cancer. Molecular medicine reports, 19(5), 4344-4352.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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