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Recombinant Mouse Anti-CD72 Recombinant Antibody (BU41) (CBMAB-XB0196-YC)

Provided herein is a Mouse Recombinant Antibody against CD72 Molecule. The antibody can be used for immunoassay techniques, such as ELISA, FC.
See all CD72 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
BU41
Antibody Isotype
IgM
Application
ELISA, FC

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD72 Molecule
Introduction
CD72 (CD72 Molecule) is a protein coding gene. Diseases associated with CD72 include Small Intestine Lymphoma and Leukemia, Chronic Lymphocytic. Among its related pathways are Semaphorin interactions and Developmental Biology. Gene Ontology annotations related to this gene include receptor binding and carbohydrate binding.
Entrez Gene ID
Human971
Mouse12517
UniProt ID
HumanP21854
MouseQ3UZ35
Alternative Names
CD72 Molecule; CD72 Antigen; Lyb-2; B-Cell Differentiation Antigen CD72; CD72b; LYB2;
Function
Plays a role in B-cell proliferation and differentiation.
Biological Process
Cell adhesion Source: ProtInc
Cellular Location
Membrane
Topology
Cytoplasmic: 1-95
Helical: 96-116
Extracellular: 117-359
PTM
Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity).

Danchenko, I. Y., Baidina, T. V., Kuklina, E. M., Trushnikova, T. N., & Nekrasova, I. V. (2021). Relapsing-remitting multiple sclerosis: clinical and immunological aspects of the pathology on the example of molecules Sema4D and CD72. Zhurnal Nevrologii i Psikhiatrii Imeni SS Korsakova, 121(7. Vyp. 2), 75-81.

Nix, M. A., Mandal, K., Geng, H., Paranjape, N., Lin, Y. H. T., Rivera, J., ... & Wiita, A. P. (2021). Surface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in KMT2A/MLL1-rearranged B-ALL. Cancer Discovery.

Zhao, C., Matsushita, T., Nguyen, V. T. H., Tennichi, M., Fujimoto, M., Takehara, K., & Hamaguchi, Y. (2020). CD22 and CD72 contribute to the development of scleroderma in a murine model. Journal of dermatological science, 97(1), 66-76.

Asmiyou, A., Bakr, A. M., Shahin, D. A., & Wahba, Y. (2020). CD40 and CD72 expression and prognostic values among children with systemic lupus erythematosus: a case–control study. Lupus, 29(10), 1270-1276.

Yang, Y., Chen, J., Tang, M., Yi, C., Gao, W., Bai, X., ... & Yang, F. (2020). Low levels of CD72 and CD100 expression on circulating lymphocytes in immunosuppressive phase of sepsis is associated with mortality in septic patients. Journal of Intensive Care, 8(1), 1-11.

Shen, Y., Ma, Y., Xie, J., Lin, L., Shi, Y., Li, X., ... & Ren, H. (2020). A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren’s syndrome. BMC immunology, 21(1), 1-6.

Nguyen, V. T. H., Matsushita, T., Zhao, C., Fujimoto, M., Takehara, K., Tedder, T. F., & Hamaguchi, Y. (2019). CD22 and CD72 cooperatively contribute to the development of the reverse Arthus reaction model. Journal of dermatological science, 95(1), 36-43.

Correa-Rocha, R., Lopez-Abente, J., Gutierrez, C., Pérez-Fernández, V. A., Prieto-Sánchez, A., Moreno-Guillen, S., ... & Pion, M. (2018). CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion. PLoS One, 13(8), e0203419.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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