Mouse Anti-CDC73 Recombinant Antibody (A097) (CBMAB-AP9846LY)

Cell Division Cycle 73

CDC73 (Cell Division Cycle 73) is a Protein Coding gene. Diseases associated with CDC73 include Hyperparathyroidism 2 With Jaw Tumors and Parathyroid Carcinoma. Among its related pathways are Metabolism of proteins and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA polymerase II core binding.

Cell Division Cycle 73; Paf1/RNA Polymerase II Complex Component; Cell Division Cycle Protein 73 Homolog; Hyperparathyroidism 2 Protein; C1orf28; HRPT2; Cell Division Cycle 73, Paf1/RNA Polymerase II Complex Component, Homolog (S. Cerevisiae); Cell Division Cycle 73 Paf1/RNA Polymerase II Complex Component-Like Protein; Cell Division Cycle 73, Paf1/RNA Polymerase II Complex Component, Homolog;

E-AB-27709

Beta-catenin-TCF complex assembly Source: Reactome
Cell cycle Source: UniProtKB-KW
Cellular response to lipopolysaccharide Source: UniProtKB
Endodermal cell fate commitment Source: UniProtKB
Histone H2B ubiquitination Source: UniProtKB
Histone monoubiquitination Source: UniProtKB
mRNA polyadenylation Source: UniProtKB
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of epithelial cell proliferation Source: UniProtKB
Negative regulation of fibroblast proliferation Source: UniProtKB
Negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Negative regulation of myeloid cell differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of cell cycle G1/S phase transition Source: UniProtKB
Positive regulation of mRNA 3'-end processing Source: UniProtKB
Positive regulation of transcription elongation from RNA polymerase II promoter Source: GO_Central
Positive regulation of Wnt signaling pathway Source: UniProtKB
Protein destabilization Source: UniProtKB
Protein ubiquitination Source: Reactome
Recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex Source: GO_Central
Regulation of cell growth Source: Ensembl
Stem cell population maintenance Source: UniProtKB
Transcription by RNA polymerase II Source: Reactome
Transcription elongation from RNA polymerase II promoter Source: GO_Central
Wnt signaling pathway Source: UniProtKB-KW

Nucleus

Hyperparathyroidism 1 (HRPT1): An autosomal dominant disorder characterized by hypercalcemia, elevated parathyroid hormone (PTH) levels, and uniglandular or multiglandular parathyroid hyperplasia, adenomas, and carcinomas.
Hyperparathyroidism 2 with jaw tumors (HRPT2): An autosomal dominant neoplasia syndrome characterized by primary hyperparathyroidism, ossifying fibroma of the maxilla and/or mandible, renal tumor, and uterine tumors. It is associated with increased risk of parathyroid cancer.
Parathyroid carcinoma (PRTC): These cancers characteristically result in more profound clinical manifestations of hyperparathyroidism than do parathyroid adenomas, the most frequent cause of primary hyperparathyroidism. Early en bloc resection of the primary tumor is the only curative treatment.

Phosphorylated. Dephosphorylated by PTPN11.