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Mouse Anti-CDNF Recombinant Antibody (6G5) (CBMAB-0217CQ)

This product is a mouse antibody that recognizes CDNF. The antibody 6G5 can be used for immunoassay techniques such as: IHC-P, WB, IF.
See all CDNF antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6G5
Antibody Isotype
IgG1
Application
IHC-P, WB, IF

Basic Information

Immunogen
Human ARMETL1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cerebral Dopamine Neurotrophic Factor
Introduction
Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionarily conserved protein family. Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra. CDNF and MANF are secreted proteins with 8 conserved cysteine residues, which predict a unique protein fold and define an evolutionarily conserved protein family. The human CDNF mRNA encodes a 187-amino acid protein with a predicted signal peptide and apparently no prosequence. The predicted secondary structure, like that of MANF, is dominated by alpha-helices. Human CDNF shares 59% amino acid identity with human MANF, and 49% and 46% identity with D. melanogaster and C. elegans Manf proteins, respectively.
Entrez Gene ID
441549
UniProt ID
Q49AH0
Alternative Names
ARMETL1
Function
Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity).
Biological Process
Dopaminergic neuron differentiation Source: GO_Central
Neuron projection development Source: GO_Central
Cellular Location
Secreted

Lindholm, P., & Saarma, M. (2021). Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism. Molecular psychiatry, 1-12.

Eremin, D. V., Ilchibaeva, T. V., & Tsybko, A. S. (2021). Cerebral Dopamine Neurotrophic Factor (CDNF): Structure, Functions, and Therapeutic Potential. Biochemistry (Moscow), 86(7), 852-866.

Stepanova, P., Srinivasan, V., Lindholm, D., & Voutilainen, M. H. (2020). Cerebral dopamine neurotrophic factor (CDNF) protects against quinolinic acid-induced toxicity in in vitro and in vivo models of Huntington’s disease. Scientific reports, 10(1), 1-12.

Kidakova, A., Boroznjak, R., Reut, J., Öpik, A., Saarma, M., & Syritski, V. (2020). Molecularly imprinted polymer-based SAW sensor for label-free detection of cerebral dopamine neurotrophic factor protein. Sensors and Actuators B: Chemical, 308, 127708.

Lindahl, M., Chalazonitis, A., Palm, E., Pakarinen, E., Danilova, T., Pham, T. D., ... & Saarma, M. (2020). Cerebral dopamine neurotrophic factor–deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice. Neurobiology of disease, 134, 104696.

Chen, Y. C., Baronio, D., Semenova, S., Abdurakhmanova, S., & Panula, P. (2020). Cerebral Dopamine Neurotrophic Factor regulates multiple neuronal subtypes and behavior. Journal of Neuroscience, 40(32), 6146-6164.

Shirvani, H., Aslani, J., Mohammadi, Z. F., & Arabzadeh, E. (2019). Short-term effect of low-, moderate-, and high-intensity exercise training on cerebral dopamine neurotrophic factor (CDNF) and oxidative stress biomarkers in brain male Wistar rats. Comparative Clinical Pathology, 28(2), 369-376.

Nasrolahi, A., Mahmoudi, J., Karimipour, M., Akbarzadeh, A., Sadigh-Eteghad, S., Salehi, R., ... & Farhoudi, M. (2019). Effect of cerebral dopamine neurotrophic factor on endogenous neural progenitor cell migration in a rat model of Parkinson's disease. EXCLI journal, 18, 139.

Zhang, G. L., Wang, L. H., Liu, X. Y., Zhang, Y. X., Hu, M. Y., Liu, L., ... & Wang, X. J. (2018). Cerebral dopamine neurotrophic factor (CDNF) has neuroprotective effects against cerebral ischemia that may occur through the endoplasmic reticulum stress pathway. International journal of molecular sciences, 19(7), 1905.

Tang, T., Li, Y., Jiao, Q., Du, X., & Jiang, H. (2017). Cerebral dopamine neurotrophic factor: a potential therapeutic agent for Parkinson’s disease. Neuroscience bulletin, 33(5), 568-575.

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For research use only. Not intended for any clinical use.

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