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Mouse Anti-CEMP1 Recombinant Antibody (CBCNC-177) (CBMAB-C2237-CN)

This product is a Mouse antibody that recognizes CEMP1. The antibody CBCNC-177 can be used for immunoassay techniques such as: ELISA, WB.
See all CEMP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNC-177
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Cementum Protein 1
Introduction
CEMP1 (Cementum Protein 1) is a Protein Coding gene. Diseases associated with CEMP1 include Coccidiosis.
Entrez Gene ID
752014
UniProt ID
Q6PRD7
Alternative Names
Cementum Protein 1; Cementum Protein 23; CP-23; Cementoblastoma-Derived Protein 1; Cementum Protein-23; CP23;
Function
May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the periodontal ligament into cementoblasts to form the cementum (PubMed:21929512, PubMed:17509525, PubMed:21465469).
Binds hydroxyapatite and may promote the biomineralization of the cementum (PubMed:19393626).
Also promotes cell proliferation (PubMed:17509525, PubMed:21929512, PubMed:26011628).
Biological Process
Biomineral tissue development Source: UniProtKB
Cell differentiation Source: UniProtKB
Cell population proliferation Source: UniProtKB
Odontogenesis Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Localizes to the nucleus of some cementoblasts.
PTM
Phosphorylated.
N-glycosylated.

Hoz, L., López, S., Zeichner‐David, M., & Arzate, H. (2021). Regeneration of rat periodontium by cementum protein 1‐derived peptide. Journal of Periodontal Research, 56(6), 1223-1232.

Lee, E., Kim, Y. S., Lee, Y. M., Kim, W. K., Lee, Y. K., & Kim, S. H. (2021). Identification of stemness and differentially expressed genes in human cementum-derived cells. Journal of Periodontal & Implant Science, 51(5), 329.

Arroyo, R., López, S., Romo, E., Montoya, G., Hoz, L., Pedraza, C., ... & Arzate, H. (2020). Carboxy-terminal cementum protein 1-derived peptide 4 (cemp1-p4) promotes mineralization through wnt/β-catenin signaling in human oral mucosa stem cells. International journal of molecular sciences, 21(4), 1307.

Kadokura, H., Yamazaki, T., Masuda, Y., Kato, Y., Hasegawa, A., Sakagami, H., & Yokose, S. (2019). Establishment of a primary culture system of human periodontal ligament cells that differentiate into cementum protein 1-expressing cementoblast-like cells. in vivo, 33(2), 349-352.

Montoya, G., Correa, R., Arenas, J., Hoz, L., Romo, E., Arroyo, R., ... & Arzate, H. (2019). Cementum protein 1‐derived peptide (CEMP 1‐p1) modulates hydroxyapatite crystal formation in vitro. Journal of Peptide Science, 25(10), e3211.

Correa, R., Arenas, J., Montoya, G., Hoz, L., López, S., Salgado, F., ... & Arzate, H. (2019). Synthetic cementum protein 1–derived peptide regulates mineralization in vitro and promotes bone regeneration in vivo. The FASEB Journal, 33(1), 1167-1178.

Villegas‐Mercado, C. E., Agredano‐Moreno, L. T., Bermúdez, M., Segura‐Valdez, M. L., Arzate, H., Del Toro‐Rangel, E. F., & Jiménez‐García, L. F. (2018). Cementum protein 1 transfection does not lead to ultrastructural changes in nucleolar organization of human gingival fibroblasts. Journal of periodontal research, 53(4), 636-642.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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