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Mouse Anti-CENPH Recombinant Antibody (CBWJC-2490) (CBMAB-C3560WJ)

This product is a Mouse antibody that recognizes CENPH. This antibody CBWJC-2490 can be used for immunoassay techniques such as: WB, IF, FC.
See all CENPH antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-2490
Antibody Isotype
IgG2b
Application
WB, IF, FC

Basic Information

Immunogen
Full length human recombinant protein of human CENPH(NP_075060) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS (PH 7.3), 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.88 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Centromere Protein H
Introduction
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]
Entrez Gene ID
64946
UniProt ID
Q9H3R5
Alternative Names
Centromere Protein H; Interphase Centromere Complex Protein 35; CENP-H; Kinetochore Protein CENP-H; ICEN35;
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
Biological Process
CENP-A containing nucleosome assembly Source: Reactome
Chromosome segregation Source: GO_Central
Kinetochore assembly Source: InterPro
Kinetochore organization Source: UniProtKB
Mitotic spindle organization Source: GO_Central
Cellular Location
Nucleus; Kinetochore. Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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