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Mouse Anti-CENPK Recombinant Antibody (10C7) (CBMAB-C0176-LY)

This product is antibody recognizes CENPK. The antibody 10C7 immunoassay techniques such as: ELISA, IHC-F, WB.
See all CENPK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10C7
Antibody Isotype
IgG1
Application
ELISA, IHC-F, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Centromere Protein K
Introduction
CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
64105
UniProt ID
Q9BS16
Alternative Names
Centromere Protein K; Interphase Centromere Complex Protein 37; Protein AF-5alpha; CENP-K; P33; SoxLZ/Sox6-Binding Protein Solt;
Function
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore.
Biological Process
CENP-A containing nucleosome assembly Source: Reactome
Kinetochore assembly Source: InterPro
Mitotic sister chromatid segregation Source: GO_Central
Mitotic spindle organization Source: Reactome
Cellular Location
Nucleus; Centromere; Kinetochore. Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Involvement in disease
Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1.

Li, Q., Liang, J., Zhang, S., An, N., Xu, L., & Ye, C. (2021). Overexpression of centromere protein K (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration. Bioengineered, 12(1), 1299-1310.

Wang, Y., Ren, C., Wang, H., Zhang, Y., & Xiu, Y. (2021). Upregulation of centromere protein K is crucial for lung adenocarcinoma cell viability and invasion. Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University.

Ma, J., Chen, X., Lin, M., Wang, Z., Wu, Y., & Li, J. (2021). Bioinformatics analysis combined with experiments predicts CENPK as a potential prognostic factor for lung adenocarcinoma. Cancer cell international, 21(1), 1-14.

Wu, S., Cao, L., Ke, L., Yan, Y., Luo, H., Hu, X., ... & He, Y. (2021). Knockdown of CENPK inhibits cell growth and facilitates apoptosis via PTEN‐PI3K‐AKT signalling pathway in gastric cancer. Journal of Cellular and Molecular Medicine, 25(18), 8890-8903.

Xie, F., Yuan, B., & Liu, J. (2021). Downregulation of CENPK suppresses lung adenocarcinoma by regulating EMT. Archives of Medical Science.

Wang, J., Li, H., Xia, C., Yang, X., Dai, B., Tao, K., & Dou, K. (2019). Downregulation of CENPK suppresses hepatocellular carcinoma malignant progression through regulating YAP1. OncoTargets and therapy, 12, 869.

Wang, H., Liu, W., Liu, L., Wu, C., Wu, W., Zheng, J., ... & Huang, J. (2017). Overexpression of centromere protein K (CENP-K) gene in hepatocellular carcinoma promote cell proliferation by activating AKT/TP53 signal pathway. Oncotarget, 8(43), 73994.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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