Rat Anti-CENPL Recombinant Antibody (CBFYC-1719) (CBMAB-C1781-FY)

This product is rat antibody that recognizes CENPL. The antibody CBFYC-1719 can be used for immunoassay techniques such as: IP, WB.
See all CENPL antibodies

Datasheet

Summary

Host Animal

Rat

Specificity

Human

Clone

CBFYC-1719

Antibody Isotype

IgG2b

Application

IP, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 50% glycerol

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

CENTROMERE PROTEIN L

Introduction

CENPL is a subunit of a CENPH-CENPI-associated centromeric complex that targets CENPA to centromeres and is required for proper kinetochore function and mitotic progression.

Entrez Gene ID

91687

UniProt ID

Q8N0S6

Alternative Names

Centromere Protein L; Interphase Centromere Complex Protein 33; C1orf155; CENP-L; Chromosome 1 Open Reading Frame 155; DJ383J4.3; ICEN33

Function

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Biological Process

CENP-A containing nucleosome assembly Source: Reactome
Mitotic spindle organization Source: Reactome

Cellular Location

Nucleus; Centromere. Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

References

Zeng, Z., Jiang, X., Pan, Z., Zhou, R., Lin, Z., Tang, Y., ... & Cao, Z. (2021). Highly expressed centromere protein L indicates adverse survival and associates with immune infiltration in hepatocellular carcinoma. Aging (Albany NY), 13(19), 22802.

Cui, Z., Xiao, L., Chen, F., Wang, J., Lin, H., Li, D., & Wu, Z. (2021). High mRNA expression of CENPL and its significance in prognosis of hepatocellular carcinoma patients. Disease Markers, 2021.

Yin, J., Lin, C., Jiang, M., Tang, X., Xie, D., Chen, J., & Ke, R. (2021). CENPL, ISG20L2, LSM4, MRPL3 are four novel hub genes and may serve as diagnostic and prognostic markers in breast cancer. Scientific reports, 11(1), 1-15.

Navarro, A. P., & Cheeseman, I. M. (2021). Dynamic cell cycle-dependent phosphorylation modulates CENP-L-CENP-N centromere recruitment. bioRxiv.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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