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Mouse Anti-CENTD2 Recombinant Antibody (ARAP1-2) (CBMAB-C9333-LY)

This product is antibody recognizes CENTD2. The antibody ARAP1-2 immunoassay techniques such as: ICC, IF, IP, WB.
See all CENTD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
ARAP1-2
Antibody Isotype
IgG1
Application
ICC, IF, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
15 mM sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1
Entrez Gene ID
116985
UniProt ID
Q96P48
Function
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).
Biological Process
Actin filament reorganization involved in cell cycle Source: UniProtKB
Negative regulation of stress fiber assembly Source: UniProtKB
Positive regulation of epidermal growth factor receptor signaling pathway Source: Reactome
Positive regulation of filopodium assembly Source: UniProtKB
Positive regulation of GTPase activity Source: UniProtKB
Positive regulation of receptor recycling Source: Ensembl
Regulation of cell shape Source: UniProtKB
Regulation of cellular component movement Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome
Signal transduction Source: InterPro
Cellular Location
Cell membrane; Golgi stack membrane; Cytoplasm. Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface and spreading.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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