Rabbit Anti-CEP41 Recombinant Antibody (EG650) (CBMAB-EN783-LY)

The product is antibody recognizes CEP41. The antibody EG650 immunoassay techniques such as: IHC: 1:50~1:100 ELISA: 1:40000.
See all CEP41 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

EG650

Antibody Isotype

IgG

Application

IHC: 1:50~1:100 ELISA: 1:40000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human CEP41.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Centrosomal Protein 41

Introduction

This gene encodes a centrosomal and microtubule-binding protein which is predicted to have two coiled-coil domains and a rhodanese domain. In human retinal pigment epithelial cells the protein localized to centrioles and cilia. Mutations in this gene have been associated with Joubert Syndrome 15; an autosomal recessive ciliopathy and neurological disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Entrez Gene ID

95681

UniProt ID

Q9BYV8

Alternative Names

Centrosomal Protein 41; Testis-Specific Gene A14 Protein; Centrosomal Protein 41kDa; Testis Specific, 14; TSGA14; Centrosomal Protein Of 41 KDa;

Function

Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium.

Biological Process

Ciliary basal body-plasma membrane docking Source: Reactome
Cilium assembly Source: UniProtKB
G2/M transition of mitotic cell cycle Source: Reactome
Protein polyglutamylation Source: UniProtKB
Protein transport Source: UniProtKB-KW
Regulation of G2/M transition of mitotic cell cycle Source: Reactome

Cellular Location

Centrosome; Cilium basal body; Cilium. Localizes mainly to the cilium basal body and in primary cilia.

Involvement in disease

Joubert syndrome 15 (JBTS15): An autosomal recessive disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy, renal disease, liver fibrosis and polydactyly.
Genetic variations in CEP41 may be associated with susceptibility to autism (PubMed:21438139).

References

Cevik, S., & Kaplan, O. I. (2021). The Joubert syndrome protein CEP41 is excluded from the distal segment of cilia in C. elegans. microPublication Biology, 2021.

Ki, S. M., Kim, J. H., Won, S. Y., Oh, S. J., Lee, I. Y., Bae, Y. K., ... & Lee, J. E. (2020). CEP 41‐mediated ciliary tubulin glutamylation drives angiogenesis through AURKA‐dependent deciliation. EMBO reports, 21(2), e48290.

Patowary, A., Won, S. Y., Oh, S. J., Nesbitt, R. R., Archer, M., Nickerson, D., ... & Brkanac, Z. (2019). Family-based exome sequencing and case-control analysis implicate CEP41 as an ASD gene. Translational psychiatry, 9(1), 1-13.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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