Sign in or Register   Sign in or Register
  |  

Mouse Anti-CERS3 Recombinant Antibody (CBYJL-094) (CBMAB-L0150-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Ceramide Synthase 3 (CERS3). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all CERS3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-094
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
LASS3 (NP_849164, 57aa-134aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 57-134

Target

Full Name
Ceramide Synthase 3
Introduction
Gene of CERS3 is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis based on the ability of catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. CERS3 has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
204219
UniProt ID
Q8IU89
Alternative Names
Ceramide Synthase 3; LAG1 Longevity Assurance Homolog 3; LAG1 Homolog; Ceramide Synthase 3; Dihydroceramide Synthase 3; LASS3; LAG1 Longevity Assurance Homolog 3 (S. Cerevisiae); EC 2.3.1.24; ARCI9; CerS3
Function
Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) and ultra long chain (more than C26:0) as acyl donor (PubMed:17977534, PubMed:22038835, PubMed:26887952).
It is crucial for the synthesis of ultra long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation (PubMed:23754960).
Biological Process
Ceramide biosynthetic process Source: UniProtKB
Cornification Source: UniProtKB
Epidermis development Source: UniProtKB
Keratinocyte differentiation Source: UniProtKB
Sphingolipid biosynthetic process Source: Reactome
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Ichthyosis, congenital, autosomal recessive 9 (ARCI9): A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CERS3 Recombinant Antibody (CBYJL-094)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare