Sign in or Register   Sign in or Register
  |  

Mouse Anti-ChemR23 / CMKLR1 Recombinant Antibody (84939) (CBMAB-C2008-YY)

This product is mouse antibody that recognizes ChemR23 / CMKLR1. The antibody 84939 can be used for immunoassay techniques such as: FC, CyTOF
See all ChemR23 / CMKLR1 antibodies
Published Data
Fig.1 Immunohistochemistry of chemR23 expression in 10-day old calvarial cultures.
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
84939
Antibody Isotype
IgG3
Application
FC, CyTOF

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human ChemR23, Met1-Leu371, Accession # NP_004063
Specificity
Human
Antibody Isotype
IgG3
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A/G purified
Preservative
PBS
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chemerin Chemokine-Like Receptor 1
Entrez Gene ID
1240
UniProt ID
Q99788
Alternative Names
DEZ; RVER1; ChemR23; CHEMERINR
Function
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
Biological Process
Chemotaxis Source: UniProtKB
Complement receptor mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: UniProtKB
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Negative regulation of interleukin-12 production Source: UniProtKB
Negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of fat cell differentiation Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: DFLAT
Regulation of calcium-mediated signaling Source: UniProtKB
Skeletal system development Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-41
Helical: 42-64
Cytoplasmic: 65-75
Helical: 76-97
Extracellular: 98-114
Helical: 115-135
Cytoplasmic: 136-154
Helical: 155-176
Extracellular: 177-224
Helical: 225-245
Cytoplasmic: 246-261
Helical: 262-282
Extracellular: 283-300
Helical: 301-320
Cytoplasmic: 321-373

Fischer, T. F., Schoeder, C. T., Zellmann, T., Stichel, J., Meiler, J., & Beck-Sickinger, A. G. (2021). Cyclic Analogues of the Chemerin C-Terminus Mimic a Loop Conformation Essential for Activating the Chemokine-like Receptor 1. Journal of Medicinal Chemistry, 64(6), 3048-3058.

Omori, A., Goshima, M., Kakuda, C., Kodama, T., Otani, K., Okada, M., & Yamawaki, H. (2020). Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats. Pflügers Archiv-European Journal of Physiology, 472(3), 335-342.

Kumar, J. D., Aolymat, I., Tiszlavicz, L., Reisz, Z., Garalla, H. M., Beynon, R., ... & Varro, A. (2019). Chemerin acts via CMKLR1 and GPR1 to stimulate migration and invasion of gastric cancer cells: putative role of decreased TIMP-1 and TIMP-2. Oncotarget, 10(2), 98.

Yao, J., Li, Z., Fu, Y., Wu, R., Wang, Y., Liu, C., ... & Zhang, H. (2019). Involvement of obesity-associated upregulation of chemerin/chemokine-like receptor 1 in oxidative stress and apoptosis in ovaries and granulosa cells. Biochemical and biophysical research communications, 510(3), 449-455.

Zhao, H., Yan, D., Xiang, L., Huang, C., Li, J., Yu, X., ... & Zhang, J. V. (2019). Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice. Cellular and Molecular Life Sciences, 76(2), 355-367.

Dranse, H. J., Zheng, A., Comeau, A. M., Langille, M. G., Zabel, B. A., & Sinal, C. J. (2018). The impact of chemerin or chemokine-like receptor 1 loss on the mouse gut microbiome. PeerJ, 6, e5494.

Perumalsamy, S., Ain Aqilah Mohd Zin, N., Teguh Widodo, R., Azman Wan Ahmad, W., Vethakkan, R. D., & Zaman Huri, H. (2017). Chemokine like receptor-1 (CMKLR-1) receptor: a potential therapeutic target in management of chemerin induced type 2 diabetes mellitus and cancer. Current pharmaceutical design, 23(25), 3689-3698.

Yang, X., Yao, J., Wei, Q., Ye, J., Yin, X., Quan, X., ... & Xing, H. (2018). Role of chemerin/CMKLR1 in the maintenance of early pregnancy. Frontiers of medicine, 12(5), 525-532.

Kennedy, A. J., & Davenport, A. P. (2018). International union of basic and clinical pharmacology CIII: chemerin receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) nomenclature, pharmacology, and function. Pharmacological Reviews, 70(1), 174-196.

Muruganandan, S., Govindarajan, R., McMullen, N. M., & Sinal, C. J. (2017). Chemokine‐like receptor 1 is a novel Wnt target gene that regulates mesenchymal stem cell differentiation. Stem Cells, 35(3), 711-724.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-ChemR23 / CMKLR1 Recombinant Antibody (84939)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare