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Mouse Anti-CHST1 Recombinant Antibody (CBFYC-1860) (CBMAB-C1924-FY)

This product is mouse antibody that recognizes CHST1. The antibody CBFYC-1860 can be used for immunoassay techniques such as: ELISA, IP, Neut.
See all CHST1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1860
Antibody Isotype
IgG
Application
ELISA, IP, Neut

Basic Information

Immunogen
Recombinant corresponding to human CHST1 expressed in CHO cells (NP_003645)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Carbohydrate Sulfotransferase 1
Introduction
This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin.
Entrez Gene ID
8534
UniProt ID
O43916
Alternative Names
Carbohydrate Sulfotransferase 1; Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 1; Carbohydrate (Keratan Sulfate Gal-6) Sulfotransferase 1; Keratan Sulfotransferase; EC 2.8.2.21; KSGal6ST; GST-1
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation.
Biological Process
Galactose metabolic process Source: UniProtKB
Inflammatory response Source: UniProtKB-KW
Keratan sulfate biosynthetic process Source: Reactome
Keratan sulfate metabolic process Source: UniProtKB
N-acetylglucosamine metabolic process Source: GO_Central
Polysaccharide metabolic process Source: ProtInc
Sulfur compound metabolic process Source: UniProtKB
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-2
Helical: 3-23
Lumenal: 24-411
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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