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Mouse Anti-CLDN10 Recombinant Antibody (CBXC-1166) (CBMAB-C1432-CQ)

This product is a mouse antibody that recognizes CLDN10. The antibody CBXC-1166 can be used for immunoassay techniques such as: FC.
See all CLDN10 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1166
Antibody Isotype
IgG2b
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Claudin 10
Introduction
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.
Entrez Gene ID
9071
UniProt ID
P78369
Alternative Names
Claudin 10; Oligodendrocyte-Specific Protein-Like; OSP-Like Protein; Claudin-10; OSP-Like; CPETRL3; HELIX; OSP-L; OSPL;
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function (PubMed:19383724, PubMed:28771254, PubMed:28686597).
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Ion transport Source: UniProtKB-KW
Regulation of ion transport Source: UniProtKB
Cellular Location
Cell membrane; Tight junction
Involvement in disease
HELIX syndrome (HELIX):
An autosomal recessive disease characterized by congenital heat intolerance, generalized anhidrosis, inability to produce tears, dry mouth, electrolyte imbalance, and ichthyosis.
Topology
Helical: 1-21
Extracellular: 22-80
Helical: 81-101
Cytoplasmic: 102-115
Helical: 116-136
Extracellular: 137-160
Helical: 161-181
Cytoplasmic: 182-228

Prot-Bertoye, C., Griveau, C., Skjødt, K., Cheval, L., Brideau, G., Lievre, L., ... & Dimke, H. (2021). Differential localization patterns of Claudin 10, 16 and 19 in human, mouse, and rat renal tubular epithelia. American Journal of Physiology-Renal Physiology.

Alzahrani, A. S., Hussein, M., Alswailem, M., Mouna, A., Albalawi, L., Moria, Y., ... & Dasouki, M. (2021). A novel claudin-10 mutation with a unique mechanism in two unrelated families with HELIX syndrome. Kidney International.

Gao, P., Peng, T., Cao, C., Lin, S., Wu, P., Huang, X., ... & Wu, P. (2021). Association of CLDN6 and CLDN10 With Immune Microenvironment in Ovarian Cancer: A Study of the Claudin Family. Frontiers in Genetics, 12.

Li, Z., Xuan, W., Huang, L., Chen, N., Hou, Z., Lu, B., ... & Huang, S. (2020). Claudin 10 acts as a novel biomarker for the prognosis of patients with ovarian cancer. Oncology letters, 20(1), 373-381.

Wang, X., Chiba, Y., Jia, L., Yoshizaki, K., Saito, K., Yamada, A., ... & Fukumoto, S. (2020). Expression Patterns of Claudin Family Members During Tooth Development and the Role of Claudin-10 (Cldn10) in Cytodifferentiation of Stratum Intermedium. Frontiers in Cell and Developmental Biology, 8.

Meyers, N., Nelson-Williams, C., Malaga-Dieguez, L., Kaufmann, H., Loring, E., Knight, J., ... & Trachtman, H. (2019). Hypokalemia associated with a claudin 10 mutation: a case report. American Journal of Kidney Diseases, 73(3), 425-428.

Milatz, S. (2019). A novel claudinopathy based on claudin-10 mutations. International journal of molecular sciences, 20(21), 5396.

Breiderhoff, T., Himmerkus, N., Drewell, H., Plain, A., Günzel, D., Mutig, K., ... & Bleich, M. (2018). Deletion of claudin-10 rescues claudin-16–deficient mice from hypomagnesemia and hypercalciuria. Kidney international, 93(3), 580-588.

Marshall, W. S., Breves, J. P., Doohan, E. M., Tipsmark, C. K., Kelly, S. P., Robertson, G. N., & Schulte, P. M. (2018). claudin-10 isoform expression and cation selectivity change with salinity in salt-secreting epithelia of Fundulus heteroclitus. Journal of Experimental Biology, 221(1), jeb168906.

Bongers, E. M., Shelton, L. M., Milatz, S., Verkaart, S., Bech, A. P., Schoots, J., ... & Nijenhuis, T. (2017). A novel hypokalemic-alkalotic salt-losing tubulopathy in patients with CLDN10 mutations. Journal of the American Society of Nephrology, 28(10), 3118-3128.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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