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Mouse Anti-CLDN14 Recombinant Antibody (CBCNC-007) (CBMAB-C0900-CN)

This product is a Mouse antibody that recognizes CLDN14. The antibody CBCNC-007 can be used for immunoassay techniques such as: ELISA, IP.
See all CLDN14 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNC-007
Antibody Isotype
IgG2a, κ
Application
ELISA, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2

Target

Full Name
claudin 14
Introduction
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]
Entrez Gene ID
23562
UniProt ID
O95500
Alternative Names
Claudin 14; Claudin-14; DFNB29;
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Protein-containing complex assembly Source: ProtInc
Cellular Location
Cell membrane; Tight junction
Involvement in disease
Deafness, autosomal recessive, 29 (DFNB29):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Topology
Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-115
Helical: 116-136
Extracellular: 137-162
Helical: 163-183
Cytoplasmic: 184-239

van Megen, W., Beggs, M., An, S. W., Ferreira, P., Lee, J., Wolf, M., ... & Dimke, H. (2022). Gentamicin Inhibits Ca2+ Channel TPRV5 and Induces Calciuresis Independent of the Calcium-Sensing Receptor-Claudin-14 Pathway. Journal of the American Society of Nephrology.

Frische, S., Alexander, R. T., Ferreira, P., Tan, R. S. G., Wang, W., Svenningsen, P., ... & Dimke, H. (2021). Localization and regulation of claudin-14 in experimental models of hypercalcemia. American Journal of Physiology-Renal Physiology, 320(1), F74-F86.

Lee, J. J., Alzamil, J., Rehman, S., Pan, W., Dimke, H., & Alexander, R. T. (2021). Activation of the calcium sensing receptor increases claudin‐14 expression via a PLC‐p38‐Sp1 pathway. The FASEB Journal, 35(11), e21982.

Ferreira, P. G., van Megen, W. H., Tan, R., Lee, C. H., Svenningsen, P., Alexander, R. T., & Dimke, H. (2021). Renal claudin-14 expression is not required for regulating Mg2+ balance in mice. American Journal of Physiology-Renal Physiology, 320(5), F897-F907.

Cai, M., Shao, J., Wang, Y., Yung, B., Li, J. N., Zhang, H. H., ... & Yao, D. B. (2021). Claudin 14/15 play important roles in early wallerian degeneration after rat sciatic nerve injury. Chinese Journal of Traumatology.

Kitano, T., Kitajiri, S. I., Nishio, S. Y., & Usami, S. I. (2019). Detailed clinical features of deafness caused by a claudin-14 variant. International journal of molecular sciences, 20(18), 4579.

Shiraiwa, Y., Daikoku, E., Saito, M., Yamashita, Y., Abe, T., Ono, F., & Kubota, T. (2018). Measurements of ionic concentrations along with endocochlear potential in wild-type and claudin 14 knockout mice. Auris Nasus Larynx, 45(3), 421-426.

Arcidiacono, T., Simonini, M., Lanzani, C., Citterio, L., Salvi, E., Barlassina, C., ... & Vezzoli, G. (2018). Claudin-14 gene polymorphisms and urine calcium excretion. Clinical Journal of the American Society of Nephrology, 13(10), 1542-1549.

Ure, M. E., Heydari, E., Pan, W., Ramesh, A., Rehman, S., Morgan, C., ... & Alexander, R. T. (2017). A variant in a cis‐regulatory element enhances claudin‐14 expression and is associated with pediatric‐onset hypercalciuria and kidney stones. Human mutation, 38(6), 649-657.

Corre, T., Olinger, E., Harris, S. E., Traglia, M., Ulivi, S., Lenarduzzi, S., ... & Devuyst, O. (2017). Common variants in CLDN14 are associated with differential excretion of magnesium over calcium in urine. Pflügers Archiv-European Journal of Physiology, 469(1), 91-103.

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For research use only. Not intended for any clinical use.

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