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Mouse Anti-CLDN20 Recombinant Antibody (4E6) (CBMAB-C6883-LY)

This product is antibody recognizes CLDN20. The antibody 4E6 immunoassay techniques such as: ELISA.
See all CLDN20 antibodies
Published Data
Fig. 1 Representative sections of tumor tissue after IHC to demonstrate increased levels of claudin-20 protein in breast cancer.
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Fig. 2 Imunofluorescent staining to show confirmation of claudin-20 overexpression in MDA-MB-231 cells.
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Fig. 3 Immunoprecipitation of some tight junction proteins by claudin-20.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E6
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Full length recombinant corresponding to aa1-220 from human CLDN20 (AAH20838) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Claudin 20
Introduction
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010]
Entrez Gene ID
49861
UniProt ID
P56880
Alternative Names
Claudin 20; Testis Secretory Sperm-Binding Protein Li 229n; Claudin-20;
Function
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Cellular Location
Cell membrane; Tight junction
Topology
Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-118
Helical: 119-139
Extracellular: 140-160
Helical: 161-181
Cytoplasmic: 182-219
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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