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Mouse Anti-CLDN8 Recombinant Antibody (474210) (CBMAB-C1337-LY)

This product is antibody recognizes CLDN8. The antibody 474210 immunoassay techniques such as: FC, ICFC, CyTOF.
See all CLDN8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
474210
Antibody Isotype
IgG1
Application
FC, ICFC, CyTOF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Claudin 8
Introduction
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]
Entrez Gene ID
9073
UniProt ID
P56748
Alternative Names
Claudin 8; Epididymis Secretory Protein Li 79; Claudin-8; HEL-S-79;
Function
Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Cellular Location
Cell membrane; Tight junction. Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells.
Topology
Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-117
Helical: 118-138
Extracellular: 139-166
Helical: 167-187
Cytoplasmic: 188-225
PTM
Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation.

Zhang, Y., Zheng, A., Lu, H., Jin, Z., Peng, Z., & Jin, F. (2020). The expression and prognostic significance of claudin-8 and androgen receptor in breast cancer. OncoTargets and therapy, 13, 3437.

Li, M., Zhao, J., Cao, M., Liu, R., Chen, G., Li, S., ... & Gong, S. (2020). Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells. Biological research, 53(1), 1-11.

Nattramilarasu, P. K., Bücker, R., Lobo de Sá, F. D., Fromm, A., Nagel, O., Lee, I. F. M., ... & Schulzke, J. D. (2020). Campylobacter concisus impairs sodium absorption in colonic epithelium via ENaC dysfunction and claudin-8 disruption. International journal of molecular sciences, 21(2), 373.

Zhou, S., Piao, X., Wang, C., Wang, R., & Song, Z. (2019). Identification of claudin‑1,‑3,‑7 and‑8 as prognostic markers in human laryngeal carcinoma. Molecular medicine reports, 20(1), 393-400.

Cheng, B., Rong, A., Zhou, Q., & Li, W. (2019). CLDN8 promotes colorectal cancer cell proliferation, migration, and invasion by activating MAPK/ERK signaling. Cancer management and research, 11, 3741.

Li, L., Huang, S., Wang, H., Chao, K., Ding, L., Feng, R., ... & Zhang, S. (2018). Cytokine IL9 triggers the pathogenesis of inflammatory bowel disease through the miR21-CLDN8 pathway. Inflammatory bowel diseases, 24(10), 2211-2223.

Nedjat-Shokouhi, B. (2018). Pathogenesis of Ulcerative Colitis: the role of Claudin-8 in epithelial barrier function and inflammation (Doctoral dissertation, UCL (University College London)).

Ashikari, D., Takayama, K. I., Obinata, D., Takahashi, S., & Inoue, S. (2017). CLDN 8, an androgen‐regulated gene, promotes prostate cancer cell proliferation and migration. Cancer science, 108(7), 1386-1393.

Qi, J., Yang, Y., Hao, P., & Xu, J. (2017). Transcription Factor SOX9 Promotes Osteosarcoma Cell Growth by Repressing Claudin-8 Expression [Retraction]. The Tohoku journal of experimental medicine, 241(1), 55-63.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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