Mouse Anti-CLEC2B Recombinant Antibody (CBCNC-015) (CBMAB-C0908-CN)

This product is a Mouse antibody that recognizes CLEC2B. The antibody CBCNC-015 can be used for immunoassay techniques such as: ELISA.
See all CLEC2B antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBCNC-015

Antibody Isotype

IgG2b, κ

Application

ELISA

Basic Information

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Target

Full Name

C-type lectin domain family 2, member B

Introduction

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Entrez Gene ID

9976

UniProt ID

Q92478

Alternative Names

C-Type Lectin Domain Family 2 Member B; C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 2 (Activation-Induced); IFN-Alpha-2b-Inducing-Related Protein 1; C-Type Lectin Superfamily Member 2; Activation-Induced C-Type Lectin; CLECSF2;

Biological Process

Regulation of immune response Source: Reactome

Cellular Location

Membrane

Topology

Cytoplasmic: 1-7
Helical: 8-25
Extracellular: 26-149

References

Yamashita, Y., Suzuki, K., Mastumoto, T., Ikejiri, M., Ohishi, K., Katayama, N., ... & Wada, H. (2019). Elevated plasma levels of soluble C-type lectin-like receptor 2 (CLEC2) in patients with thrombotic microangiopathy. Thrombosis research, 178, 54-58.

Sung, P. S., & Hsieh, S. L. (2019). CLEC2 and CLEC5A: pathogenic host factors in acute viral infections. Frontiers in immunology, 10, 2867.

Sung, P. S., Huang, T. F., & Hsieh, S. L. (2019). Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2. Nature communications, 10(1), 1-13.

Varaden, D., Moodley, J., Onyangunga, O. A., & Naicker, T. (2019). Morphometric image analysis of placental C-type lectin domain family 2, member D (CLEC2D) immuno-expression in HIV associated pre-eclampsia. European journal of obstetrics & gynecology and reproductive biology: X, 3, 100039.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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