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Mouse Anti-CLEC4D Recombinant Antibody (CBYY-C3261) (CBMAB-C4705-YY)

This product is mouse antibody that recognizes CLEC4D. The antibody CBYY-C3261 can be used for immunoassay techniques such as: ELISA, FC, WB
See all CLEC4D antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C3261
Antibody Isotype
IgG2b
Application
ELISA, FC, WB

Basic Information

Immunogen
NS0-derived recombinant human CLEC4D (aa52-215) UniProt # Q8WXI8
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Preservative
50% glycerol, PBS, 5% trehalose
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-Type Lectin Domain Family 4 Member D
Entrez Gene ID
338339
UniProt ID
Q8WXI8
Alternative Names
Ectonucleoside Triphosphate Diphosphohydrolase 6 (Putative); Interleukin 6 Signal Transducer-2; CD39 Antigen-Like 2; NTPDase 6; CD39L2; IL6ST2;
Function
Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:23602766, PubMed:23911656).

The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed:23602766, PubMed:23911656).

Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity).

Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766, PubMed:23911656).

The heterodimer formed with CLEC6A is active against fungal infection (PubMed:23911656).

Functions as an endocytic receptor (PubMed:14971047).

May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (PubMed:14971047).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Neutrophil degranulation Source: Reactome
Positive regulation of myeloid dendritic cell activation Source: UniProtKB
Stimulatory C-type lectin receptor signaling pathway Source: Reactome
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-215
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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