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Mouse Anti-CNBP Recombinant Antibody (38F10) (CBMAB-C1058-LY)

This product is antibody recognizes CNBP. The antibody 38F10 immunoassay techniques such as: WB, FC, ELISA, ICC/IF.
See all CNBP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
38F10
Antibody Isotype
IgG2b, κ
Application
WB, FC, ELISA, ICC/IF

Basic Information

Immunogen
Recombinant human CNBP (1-170aa) purified from E. coli
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CCHC-Type Zinc Finger Nucleic Acid Binding Protein
Introduction
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
Entrez Gene ID
7555
UniProt ID
P62633
Alternative Names
CCHC-Type Zinc Finger Nucleic Acid Binding Protein; Zinc Finger Protein 9 (A Cellular Retroviral Nucleic Acid Binding Protein); Zinc Finger Protein 9; RNF163; ZNF9; CCHC-Type Zinc Finger, Nucleic Acid Binding Protein; Sterol Regulatory Element-Binding Pro
Function
Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.
Biological Process
Cholesterol homeostasis Source: GO_Central
G-quadruplex DNA formation Source: ARUK-UCL
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of cytoplasmic translation Source: GO_Central
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription, DNA-templated Source: ProtInc
Cellular Location
Endoplasmic reticulum; Cytoplasm
Involvement in disease
Dystrophia myotonica 2 (DM2):
The disease is caused by variants affecting the gene represented in this entry. The causative mutation is a CCTG expansion (mean approximately 5000 repeats) located in intron 1 of the CNBP gene. A multisystem disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Additional features can include hyperhidrosis, testicular atrophy, insulin resistance and diabetes and central nervous system anomalies in rare cases.
PTM
Arginine methylation by PRMT1 in the Arg/Gly-rich region impedes RNA binding.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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