Mouse Anti-CNGA1 Recombinant Antibody (CBWJC-2851) (CBMAB-C3975WJ)

This product is a Mouse antibody that recognizes CNGA1. This antibody CBWJC-2851 can be used for immunoassay techniques such as: ICC, IF, IHC, WB.
See all CNGA1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

CBWJC-2851

Antibody Isotype

IgG1

Application

ICC, IF, IHC, WB

Basic Information

Immunogen

MBP-fusion protein of the C-terminal region of the a2 subunit (aaK581-D670)

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Preservative

0.05% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Cyclic Nucleotide Gated Channel Alpha 1

Introduction

CNGA2 (Cyclic Nucleotide Gated Channel Alpha 2) is a Protein Coding gene. Diseases associated with CNGA2 include Anosmia, Isolated Congenital and Cranial Nerve Malignant Neoplasm. Among its related pathways are Organelle biogenesis and maintenance and cAMP signaling pathway. Gene Ontology (GO) annotations related to this gene include calmodulin binding and voltage-gated potassium channel activity. An important paralog of this gene is CNGA3.

Entrez Gene ID

Human	1259
Mouse	12788
Rat	85259

UniProt ID

Human	P29973
Mouse	P29974
Rat	Q62927

Alternative Names

Cyclic Nucleotide Gated Channel Alpha 1; Rod Photoreceptor CGMP-Gated Channel Subunit Alpha; Cyclic Nucleotide-Gated Channel, Photoreceptor; Cyclic Nucleotide-Gated Cation Channel 1; CNG Channel Alpha-1; CNCG1; CNG-1; CNCG; CNG1;

Function

Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.

Biological Process

Regulation of rhodopsin mediated signaling pathway Source: Reactome
Rhodopsin mediated signaling pathway Source: Reactome
Visual perception Source: ProtInc

Cellular Location

Cell membrane

Involvement in disease

Retinitis pigmentosa 49 (RP49):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

Topology

Cytoplasmic: 1-164
Helical: 165-185
Extracellular: 186-198
Helical: 199-217
Cytoplasmic: 218-239
Helical: 240-259
Extracellular: 260-266
Helical: 267-288
Cytoplasmic: 289-299
Helical: 300-326
Extracellular: 327-369
Helical: 370-401
Cytoplasmic: 402-690

References

Liu, Y., Wang, Y., Xiao, Y., Li, X., Ruan, S., Luo, X., ... & Sun, X. (2021). Retinal degeneration in mice lacking the cyclic nucleotide‐gated channel subunit CNGA1. The FASEB Journal, 35(9), e21859.

Xue, J., Han, Y., Zeng, W., Wang, Y., & Jiang, Y. (2021). Structural mechanisms of gating and selectivity of human rod CNGA1 channel. Neuron, 109(8), 1302-1313.

Wang, L., Zou, T., Lin, Y., Li, L., Zhang, P., Gong, B., ... & Zhang, H. (2020). Identification of a novel homozygous variant in the CNGA1 gene in a Chinese family with autosomal recessive retinitis pigmentosa. Molecular Medicine Reports, 22(3), 2516-2520.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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