Rabbit Anti-CNKSR1 Recombinant Antibody (EG746) (CBMAB-EN901-LY)

The product is antibody recognizes CNKR1. The antibody EG746 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all CNKSR1 antibodies

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

EG746

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human CNKR1.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Connector Enhancer Of Kinase Suppressor Of Ras 1

Entrez Gene ID

Human	10256
Mouse	194231
Rat	298545

UniProt ID

Human	Q969H4
Mouse	A2A9K7
Rat	Q499S0

Function

May function as an adapter protein or regulator of Ras signaling pathways.

Biological Process

Ras protein signal transduction Source: MGI
Rho protein signal transduction Source: MGI
Transmembrane receptor protein tyrosine kinase signaling pathway Source: ProtInc

Cellular Location

Cytoplasm; Membrane

PTM

Phosphorylated on tyrosine.

References

Nishiyama, K., Maekawa, M., Nakagita, T., Nakayama, J., Kiyoi, T., Chosei, M., ... & Higashiyama, S. (2021). CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP. Life Science Alliance, 4(9).

Kazeminasab, S., Taskiran, I. I., Fattahi, Z., Bazazzadegan, N., Hosseini, M., Rahimi, M., ... & Kahrizi, K. (2018). CNKSR1 gene defect can cause syndromic autosomal recessive intellectual disability. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 177(8), 691-699.

Quadri, H. S., Aiken, T. J., Allgaeuer, M., Moravec, R., Altekruse, S., Hussain, S. P., ... & Rudloff, U. (2017). Expression of the scaffold connector enhancer of kinase suppressor of Ras 1 (CNKSR1) is correlated with clinical outcome in pancreatic cancer. BMC cancer, 17(1), 1-12.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-CNKSR1 Recombinant Antibody (CBWJC-2852)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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