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Mouse Anti-CNN3 Recombinant Antibody (4C4) (CBMAB-C6732-LY)

This product is antibody recognizes CNN3. The antibody 4C4 immunoassay techniques such as: ELISA, WB.
See all CNN3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4C4
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
calponin 3, acidic
Introduction
CNNM1 (Cyclin And CBS Domain Divalent Metal Cation Transport Mediator 1) is a Protein Coding gene. Diseases associated with CNNM1 include Urofacial Syndrome 1. Gene Ontology (GO) annotations related to this gene include adenyl nucleotide binding. An important paralog of this gene is CNNM2.
Entrez Gene ID
1266
UniProt ID
Q15417
Alternative Names
Calponin 3; Calponin, Acidic Isoform; Calponin 3, Acidic; DJ639P13.2.2 (Acidic Calponin 3); Calponin-3;
Function
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.
Biological Process
Actomyosin structure organization Source: InterPro
Epithelial cell differentiation Source: UniProtKB
Negative regulation of ATPase activity Source: Ensembl
Cellular Location
Actin cytoskeleton; Cytosol; Adherens junction; Dendritic spine; Focal adhesion; Neuronal cell body; Postsynaptic density

Yang, C., Zhu, S., Feng, W., & Chen, X. (2021). Calponin 3 suppresses proliferation, migration and invasion of non‑small cell lung cancer cells. Oncology Letters, 22(2), 1-9.

She, Y., Li, C., Jiang, T., Lei, S., Zhou, S., Shi, H., & Chen, R. (2021). Knockdown of CNN3 Impairs Myoblast Proliferation, Differentiation, and Protein Synthesis via the mTOR Pathway. Frontiers in physiology, 12, 862.

Maddala, R., Mongan, M., Xia, Y., & Rao, P. V. (2020). Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap/Taz transcriptional activation in lens epithelial cells and explants. Scientific reports, 10(1), 1-15.

Dai, F., Luo, F., Zhou, R., Zhou, Q., Xu, J., Zhang, Z., ... & Song, L. (2020). Calponin 3 is associated with poor prognosis and regulates proliferation and metastasis in osteosarcoma. Aging (Albany NY), 12(14), 14037.

Xia, L., Yue, Y., Li, M., Zhang, Y. N., Zhao, L., Lu, W., ... & Xie, X. (2020). CNN3 acts as a potential oncogene in cervical cancer by affecting RPLP1 mRNA expression. Scientific reports, 10(1), 1-10.

Ma, C., Gu, R., Wang, X., He, S., Bai, J., Zhang, L., ... & Zhu, D. (2020). circRNA CDR1as promotes pulmonary artery smooth muscle cell calcification by Upregulating CAMK2D and CNN3 via sponging miR-7-5p. Molecular Therapy-Nucleic Acids, 22, 530-541.

Nair, V. A., Al-Khayyal, N. A., Sivaperumal, S., & Abdel-Rahman, W. M. (2019). Calponin 3 promotes invasion and drug resistance of colon cancer cells. World Journal of Gastrointestinal Oncology, 11(11), 971.

Hong, K. S., Kim, H., Kim, S. H., Kim, M., & Yoo, J. (2019). Calponin 3 regulates cell invasion and doxorubicin resistance in gastric cancer. Gastroenterology Research and Practice, 2019.

Ciuba, K., Hawkes, W., Tojkander, S., Kogan, K., Engel, U., Iskratsch, T., & Lappalainen, P. (2018). Calponin-3 is critical for coordinated contractility of actin stress fibers. Scientific reports, 8(1), 1-11.

Abdel-Rahman, W. M., Nair, V., & Al-khayyal, N. (2018). PO-206 Calponin 3 (CNN3) promotes epithelial to mesenchymal transition and drug resistance of colon cancer cells. ESMO Open, 3, A100-A101.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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