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Mouse Anti-CNOT2 Recombinant Antibody (10B2274) (CBMAB-C2179-LY)

This product is antibody recognizes CNOT2. The antibody 10B2274 immunoassay techniques such as: ELISA, WB.
See all CNOT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10B2274
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CCR4-NOT Transcription Complex Subunit 2
Introduction
CNOT4 (CCR4-NOT Transcription Complex Subunit 4) is a Protein Coding gene. Diseases associated with CNOT4 include Adenoiditis. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding.
Entrez Gene ID
4848
UniProt ID
Q9NZN8
Alternative Names
CCR4-NOT Transcription Complex Subunit 2; CCR4-Associated Factor 2; CDC36; NOT2; CCR4-NOT Transcription Complex, Subunit 2; Negative Regulator Of Transcription 2; HSPC131; NOT2H;
Function
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Gene silencing by RNA Source: UniProtKB-KW
Negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Nuclear-transcribed mRNA poly(A) tail shortening Source: GO_Central
Positive regulation of cytoplasmic mRNA processing body assembly Source: UniProtKB
Regulation of stem cell population maintenance Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of translation Source: UniProtKB-KW
RNA phosphodiester bond hydrolysis, exonucleolytic Source: GOC
Trophectodermal cell differentiation Source: Ensembl
Cellular Location
Nucleus; Cytoplasm
Involvement in disease
Intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies (IDNADFS):
An autosomal dominant disorder characterized by delayed development, speech delay with nasal speech, and characteristic facial features including upslanted palpebral fissures, anteverted nares, a thin upper lip, and micrognathia. Some patients may have skeletal anomalies, such as brachydactyly, toe syndactyly and flat feet.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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