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Rabbit Anti-CNOT3 Recombinant Antibody (CBWJC-2865) (CBMAB-C3991WJ)

This product is a Rabbit antibody that recognizes CNOT3. This antibody CBWJC-2865 can be used for immunoassay techniques such as: IP, WB.
See all CNOT3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey, Mouse, Rat
Clone
CBWJC-2865
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to human CNOT3 at C-terminal
Specificity
Human, Monkey, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
10mM sodium HEPES, pH 7.5, 100ug/ml BSA, 150mM sodium chloride, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CCR4-NOT Transcription Complex Subunit 3
Introduction
CNOT3 (CCR4-NOT Transcription Complex Subunit 3) is a Protein Coding gene. Diseases associated with CNOT3 include Precursor T-Cell Acute Lymphoblastic Leukemia and Retrograde Amnesia. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay.
Entrez Gene ID
Human4849
Mouse232791
Rat308311
Monkey693292
UniProt ID
HumanO75175
MouseQ8K0V4
RatD3ZUV9
MonkeyH2R0F5
Alternative Names
CCR4-NOT Transcription Complex Subunit 3; NOT3 (Negative Regulator Of Transcription 3, Yeast) Homolog; Leukocyte Receptor Cluster Member 2; CCR4-Associated Factor 3; LENG2; NOT3; CCR4-NOT Transcription Complex, Subunit 3; KIAA0691; NOT3H;
Function
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
Biological Process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Gene silencing by RNA Source: UniProtKB-KW
Nuclear-transcribed mRNA poly(A) tail shortening Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Regulation of stem cell population maintenance Source: UniProtKB
Regulation of transcription, DNA-templated Source: InterPro
Regulation of translation Source: UniProtKB-KW
Trophectodermal cell differentiation Source: Ensembl
Cellular Location
Cytoplasm; Nucleus; P-body. NANOS2 promotes its localization to P-body.
Involvement in disease
Intellectual developmental disorder with speech delay, autism and dysmorphic facies (IDDSADF):
An autosomal dominant disorder characterized by mild to severe intellectual disability, developmental delay, delayed or absent speech, hypotonia, short stature, autistic features, and highly variable dysmorphic facial features.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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